681 Building an improved humanized mouse model of psoriasis for drug discovery

In vivo models of psoriasis are needed for preclinical testing of new therapeutics, but none has adequately reflected the morphology, mRNA, and protein expression of psoriasis. Mouse models incorporating human epidermal, dermal, and immune cells have the potential to more closely reflect human psoriatic tissue. We generated human skin 3D cultures which were grafted onto NSG mice, leading to ≥80% graft acceptance and 10% contraction compared to ≤50% graft take and 60% contraction observed in nude mice.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pharmacology and Drug Development Source Type: research