Human serum RNase-L level is inversely associated with metabolic syndrome and age

Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents. Here, we develo...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research

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CONCLUSION: Metformin is an effective, well tolerated and inexpensive treatment, that represents a viable treatment option for HS. Key message: Metformin is an effective, well tolerated and inexpensive treatment in the management of HS. PMID: 30893570 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
AbstractIntroduction/PurposeMetabolic syndrome is commonly demonstrated in patients with morbid obesity undergoing bariatric surgery. The purpose of this study was to determine the effect of metabolic syndrome on morbidity and mortality following bariatric surgery.Materials and MethodsThe National Surgical Quality Improvement Program (NSQIP) dataset was queried for patients who underwent bariatric surgical procedures between 2012 and 2014. Patient demographics, comorbid conditions, bariatric procedure type, and postoperative complications were analyzed. Metabolic syndrome was defined as having a body mass index> &thinsp...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Authors: Aldret RL, Bellar D Abstract The purpose of the present study was to examine whether 14 days of supplementation with maritime pine extract leading up to and following an exercise test would increase performance and reduce biomarkers associated with muscle damage, inflammation, and oxidative stress. The study used a double-blind, placebo-controlled, cross-over design. Twenty apparently healthy young male participants ingested either 800 mg pine bark extract or placebo for 14 days prior to the first exercise trial and for 2 days postexercise. On the exercise day, participants subm...
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
This study evaluates the effects of Coenzyme Q10 (CoQ10) supplementation on different lifestyles, in relation to serum and tissue OS parameters. MATERIALS AND METHODS: Twelve Wistar rat groups (10 rats/group) were equally divided in three types of diets: standard (St), high fat (HF), high sugar (HS); within each diet group there was one sedentary group with CoQ10 supplementation (100 mg/kg body weight), one sedentary without CoQ10, one trained group with CoQ10 and one trained group without CoQ10 supplementation. After 28 days blood samples were collected as follows: after 12 hours of fasting (T0), 1 hour postprand...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Conclusion: While exercise affects food intake, source of protein determines BW and BC. Whey protein showed more favorable effect on BW and body composition.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Rasheeba Nizam, Ebaa Al-Ozairi, Jo Max Goodson, Motesam Melhem, Lena Davidsson, Hessa Alkhandari, Ashraf Al Madhoun, Sara Shamsah, Malak Qaddoumi, Ghazi Alghanim, Nouf Alhasawi, Mohamed Abu-Farha, Jehad Abubaker, Ping Shi, Mor-Li Hartman, Mary Tavares, Milad Bitar, Hamad Ali, Hossein Arefanian, Sriraman Devarajan, Faisal Al-Refaei, Osama Alsmadi, Jaakko Tuomilehto, Fahd Al-Mulla
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study was to investigate an association of incident MetS with levels of HbA1c and fasting glucose.MethodsIn a cohort of Korean Genome and Epidemiology Study, 5515 non-diabetic adults were grouped by the levels of baseline fasting glucose and HbA1c, and followed-up for 10  years. Using multivariate Cox proportional hazards assumption, hazards ratios (HRs) and 95% confidence interval (CI) for incident MetS (adjusted HRs [95% CI]) were calculated according to baseline fasting glucose and HbA1c. In individuals with normal fasting glucose, subgroup analysis was conducte d to evaluate an association of HbA1c levels wit...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Conclusions: The results indicated that probiotic food and supplement withLactobacillus andBifidobacterium could be used as interventions to improve specific anthropometric and biochemical outcomes among individuals withMetS. However, probiotic treatment alone could not reduce overall health risks. In addition, there were methodological drawbacks among reviewed studies, and further research is needed.Ann Nutr Metab 2019;74:224 –241
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes.
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: Available online 19 March 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Nayara Ragi Baldoni, Jéssica Azevedo Aquino, Geisa Cristina Silva Alves, Daniela Saes Sartoreli, Laercio Joel Franco, Sofia Pereira Madeira, Amaury Lelis Dal FabbroAbstractTo carry out a systematic review to identify the prevalence of overweight and obesity in the adult indigenous population in Brazil. The databases used were PubMed, Scopus, Virtual Health Library (VHL), and Science Direct, with the following search strategy: “overweight” OR “obesity” AND “i...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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