Metabolic mechanism identified for R-LA induced cell death in liver cancer cells

(Mary Ann Liebert, Inc./Genetic Engineering News) A new study that measured metabolite levels over time in starved rat liver cancer cells showed that treatment with a form of alpha-lipoic acid (LA) inhibited glucose uptake and glycolysis, and led to decreased cellular glucose production from non-carbohydrate sources, which may help explain how the naturally occurring R enantiomeric form of LA (R-LA) promotes the death of hepatoma cells.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news