BMP-9 interferes with liver regeneration and promotes liver fibrosis

Conclusions
Constitutive expression of low levels of BMP-9 stabilises hepatocyte function in the healthy liver. Upon HSC activation, endogenous BMP-9 levels increase in vitro and in vivo and high levels of BMP-9 cause enhanced damage upon acute or chronic injury.

Source: Gut - April 7, 2017 Category: Gastroenterology Authors: Breitkopf-Heinlein, K., Meyer, C., König, C., Gaitantzi, H., Addante, A., Thomas, M., Wiercinska, E., Cai, C., Li, Q., Wan, F., Hellerbrand, C., Valous, N. A., Hahnel, M., Ehlting, C., Bode, J. G., Müller-Bohl, S., Klingmüller, U., Tags: Editor's choice Hepatology Source Type: research