IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

Conclusions
IL-36R signalling is activated upon intestinal damage, stimulates IECs and fibroblasts and drives mucosal healing. Modulation of the IL-36R pathway emerges as a potential therapeutic strategy for induction of mucosal healing in IBD.

Source: Gut - April 7, 2017 Category: Gastroenterology Authors: Scheibe, K., Backert, I., Wirtz, S., Hueber, A., Schett, G., Vieth, M., Probst, H. C., Bopp, T., Neurath, M. F., Neufert, C. Tags: Inflammatory bowel disease Source Type: research