Helicobacter pylori-induced cell death is counteracted by NF-{kappa}B-mediated transcription of DARPP-32

Conclusions
Given the high frequency of DARPP-32 overexpression and its prosurvival oncogenic functions, the induction of DARPP-32 expression following H. pylori infection and activation of NF-B provides a link between infection, inflammation and gastric tumourigenesis.

Source: Gut - April 7, 2017 Category: Gastroenterology Authors: Zhu, S., Soutto, M., Chen, Z., Peng, D., Romero-Gallo, J., Krishna, U. S., Belkhiri, A., Washington, M. K., Peek, R., El-Rifai, W. Tags: Campylobacter, Salmonella, Shigella, Escherichia coli, Helicobacter pylori, Pancreatic cancer Upper GI cancer Source Type: research