Busulfan drug monitoring is needed in patients undergoing allogeneic stem cell transplantation

Publication date: Available online 6 April 2017 Source:Hematology/Oncology and Stem Cell Therapy Author(s): Bushra Salman, Mohammed Al-Zaabi, Mohammed Al-Huneini, David Dennison, Abdulhakeem Al-Rawas, Salam Al-Kindi, Khalil Al-Farsi, Melanie Tauro, Murtadha Al-Khabori Busulfan (Bu)-based preparative regimens in hematopoietic stem cell transplantation are commonly used. Previous studies have shown that Bu at a fixed dose of 3.2mg/kg/day (FBD) given intravenously decreases variability in drug pharmacokinetics and this decreases the dependency on therapeutic drug monitoring (TDM) of Bu. We compared the Bu dose given using TDM with the FBD of 3.2mg/kg/day. Seventy-three patients with acute leukemia, myelodysplasia, chronic myeloid leukemia, thalassemia major, and sickle cell disease were included. The mean age at transplant was 15years (range 2–55years) with 57% adults. Indication for transplantation was leukemia/myelodysplastic syndrome in 46% of the patients, while the remaining 54% were transplanted for inherited blood disorders. We found that the median FBD was lower than the median TDM dose by 39mg/day with a statistically significant difference (p <0.001) even after adjusting for the weight (median total FBD of 349mg, median TDM dose of 494mg, p <0.0001). Age and underlying condition (malignant vs. nonmalignant) were the main factors affecting Bu clearance (p <0.001 and p <0.07, respectively). TDM remains an important tool for the ap...
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research