Acute and Chronic Micro- and Macrovascular Lesions in Pancreas Transplants: Implications for the Diagnosis of T Cell-Mediated and Antibody-Mediated Allograft Rejection

AbstractPurpose of ReviewT cell-mediated and antibody-mediated rejections are recognized as the main rejection pathways in pancreas transplantation. In comparison to other organs, rejection-related vascular lesions have not been described systematically yet.Recent FindingsTissue involvement in acute and chronic T cell-mediated and antibody-mediated rejections are very distinctive with respect to the epithelial components and the microvasculature, but have overlapping features regarding larger arterial branches. More specifically, the microvasculature (predominantly represented by the interacinar capillaries) which is targeted and potentially destroyed rapidly in acute antibody-mediated rejection is largely uninvolved in acute T cell-mediated rejection. In larger arteries, intimal arteritis and even arterial necrosis may be present in both types of rejection in the acute phase. Similarly in the chronic phase, both types of rejection can lead to transplant arteriopathy.SummaryRecognition of the distinctive, as well as common lesions is essential for accurate diagnosis. Future molecular studies will provide additional insight in mechanisms of vascular rejection in the pancreas.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
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Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
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Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
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Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
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Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
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