Genetic Effects on the Correlation Structure of CVD Risk Factors
Plasma concentration of plasminogen activator inhibitor-1 (PAI-1) is highly correlated with several cardiovascular disease (CVD) risk factors. It also plays a direct role in CVD, including myocardial infarction and stroke, by impeding the dissolution of thrombi in the blood. Insofar as PAI-1 links CVD's risk factors to its endpoints, genetic variants modulating the relationship between PAI-1 and risk factors may be of particular clinical and biological interest. The high heritability of PAI-1, which has not been explained by genetic association studies, may also, in large part, be due to this relationship with CVD risk factors.
Source: CVD Prevention and Control - Category: Global & Universal Authors: Nuri Kodaman, Rafal S. Sobota, Folkert W. Asselbergs, Matthew T. Oetjens, Jason H. Moore, Nancy J. Brown, Melinda C. Aldrich, Scott M. Williams Tags: Review Source Type: research
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