Novel Augmentation Strategies in Major Depression.

Novel Augmentation Strategies in Major Depression. Dan Med J. 2017 Apr;64(4): Authors: Martiny K Abstract Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration. In the first five weeks of the study, patients were randomised to treatment with either 60 minutes of bright white or 30 minutes of dim red light (sham condition). In the four weeks follow-up period, patients were treated with sertraline alone. In the Pindolol study, all patients were treated with venlafaxine and randomised to augmentation with either active or placebo matching pindolol tablets. In the PEMF study patients were continued on ongoing medication and randomised to augmentation with active or inactive (sham) 30 minutes daily PEMF treatment on weekdays. In the Chronos study all patients were treated with duloxetine and randomized to either a combination of three wake therapies with daily bright light treatment and sleep time stabilisation (w...
Source: Danish Medical Journal - Category: Journals (General) Tags: Dan Med J Source Type: research

Related Links:

Abstract Patient diurnal mood fluctuation, sleep characteristics and factors affecting sleep homeostasis predict antidepressant response to the combination of total sleep deprivation and light therapy (TSD + LT). In order to study if chronotype could influence response to TSD+LT, we considered 194 bipolar depressed patients. Severity of depression was rated with Hamilton Depression Rating Scale; perceived mood levels were assessed by a self-administered 10-cm visual analogue scale and chronotype was assessed using the Mornigness-Eveningness Questionnaire. More than 60% of patients resulted responders to ...
Source: Chronobiology International - Category: Biology Authors: Tags: Chronobiol Int Source Type: research
The use of light for its antidepressant action dates back to the  beginnings of civilization. As early as 4700 y ago, Wong Tai mentioned the fluctuation of diseases with seasons, Hippocrates wrote on the interrelation between seasonal climates and mood (melancholia and mania) [1], and Aretaeus of Cappadocia prescribed, in the second century AD, that “Lethargi cs be laid in the light, and exposed to the rays of the sun, for the disease is gloom”. While being reported for millennia, bright light therapy (BLT) in depression was not officially recognized until 30 y ago for treating the Seasonal Affec...
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Tags: Letter to the editor Source Type: research
The use of light for its antidepressant action dates back to the beginnings of civilization. As early as 4700 years ago, Wong Tai mentioned the fluctuation of diseases with seasons, Hippocrates wrote on the interrelation between seasonal climates and mood (melancholia and mania) [1], and Aretaeus of Cappadocia prescribed, in the second century AD, that “Lethargics be laid in the light, and exposed to the rays of the sun, for the disease is gloom”. While being reported for millennia, bright light therapy (BLT) in depression was not officially recognized until 30 years ago for treating the Seasonal Affective Diso...
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Tags: Letter to the editor Source Type: research
Our society tends to dismiss seasonal affective disorder (SAD). We minimize it. We misunderstand it. Oh, you just don’t like winter. And who could blame you? Winter is tough on everyone. Oh, SAD is like the winter blues, right? You get grumpy or moody because you hate the freezing cold. You’re just in a funk. It happens to a lot of people. It’s totally normal. How can you feel depressed when the air is so crisp and it’s a winter wonderland out there? We incorporate SAD into our vocabulary, flippantly using it in conversation. “Similar to someone saying “I can’t make up my mind, it...
Source: Psych Central - Category: Psychiatry Authors: Tags: Depression Disorders General Seasonal Affective Disorder Stigma Light therapy Mental Health Stigma phototherapy SAD summer depression summertime depression winter depression wintertime depression Source Type: news
The combination of three cycles of sleep deprivation (SD), light therapy (LT), and lithium has recently been proposed as a possible first-line treatment for bipolar depression. However, it is unclear whether early improvement predicts final response/remission in bipolar depression treated with this regimen.
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research
Conclusions rs7713917 influenced brain grey and white matter structure and function in BD, long term effects of lithium on white matter structure, and antidepressant response to chronotherapeutics, thus suggesting that glutamatergic neuroplasticity and Homer 1 function might play a role in BD psychopathology and response to treatment.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
It’s that time of year again when the highly sensitive types among us who thrive with lots of sunlight begin to wither with the plants as the sun begins to hide. Not only do we get less vitamin D (and deficiencies have been linked to depression), but the change in sunlight affects our circadian rhythm — the body’s internal biological clock that governs certain brain activity and hormone production. In some people, the change of mood-related chemicals can cause seasonal affective disorder (SAD), also known as winter blues or seasonal depression. For an episode of major depression to be class...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alternative and Nutritional Supplements Bipolar Depression Holiday Coping Mental Health and Wellness Roundup Self-Help Light therapy Sad Sadness Seasonal Affective Disorder Seasonal Depression seasonal depressive disorder Vitamin Source Type: blogs
By Christian Jarrett The clocks have gone back and there’s a chill in the air. It’s well known that during these darker months, a significant minority of us experience unwelcome negative changes to our mood (at least if you believe in the notion of Seasonal Affective Disorder or SAD, which not all experts do). Now an intriguing study in Psychiatry Research has explored the link this condition may have with another psychiatric diagnosis, Obsessive Compulsive Disorder (OCD). The results suggest that people with OCD are more likely than average to experience seasonal effects on their mood, and that for these ...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Mental health Source Type: blogs
Adjunctive bright light therapy may help lower depressive symptoms in adults with bipolar disorder, reports astudy published yesterday inAJP in Advance.“Despite advances in drug treatment for mania, the development of effective pharmacotherapy for bipolar depression remains a challenge,” wrote Dorothy Sit, M.D., of the University of Pittsburgh and colleagues. “Given the limited treatment options, research to investigate novel therapeutics for bipolar depression is a high-priority public health concern.”Much like patients with major depression, people with bipolar disorder commonly report sleep probl...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance bipolar depression bipolar disorder circadian rhythm Dorothy Kit light therapy SIGH-ADS sleep Source Type: research
CONCLUSIONS: The data from this study provide robust evidence that supports the efficacy of midday bright light therapy for bipolar depression. PMID: 28969438 [PubMed - as supplied by publisher]
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
More News: Advertising | Bipolar | Cymbalta | Depression | Effexor | General Medicine | Light Therapy | Mania | Men | Psychiatry | Sertraline | Sleep Disorders | Sleep Medicine | Sports Medicine | Statistics | Study | Thyroid | Zoloft