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Novel Augmentation Strategies in Major Depression.

Novel Augmentation Strategies in Major Depression. Dan Med J. 2017 Apr;64(4): Authors: Martiny K Abstract Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration. In the first five weeks of the study, patients were randomised to treatment with either 60 minutes of bright white or 30 minutes of dim red light (sham condition). In the four weeks follow-up period, patients were treated with sertraline alone. In the Pindolol study, all patients were treated with venlafaxine and randomised to augmentation with either active or placebo matching pindolol tablets. In the PEMF study patients were continued on ongoing medication and randomised to augmentation with active or inactive (sham) 30 minutes daily PEMF treatment on weekdays. In the Chronos study all patients were treated with duloxetine and randomized to either a combination of three wake therapies with daily bright light treatment and sleep time stabilisation (w...
Source: Danish Medical Journal - Category: Journals (General) Tags: Dan Med J Source Type: research

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Adjunctive bright light therapy may help lower depressive symptoms in adults with bipolar disorder, reports astudy published yesterday inAJP in Advance.“Despite advances in drug treatment for mania, the development of effective pharmacotherapy for bipolar depression remains a challenge,” wrote Dorothy Sit, M.D., of the University of Pittsburgh and colleagues. “Given the limited treatment options, research to investigate novel therapeutics for bipolar depression is a high-priority public health concern.”Much like patients with major depression, people with bipolar disorder commonly report sleep probl...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance bipolar depression bipolar disorder circadian rhythm Dorothy Kit light therapy SIGH-ADS sleep Source Type: research
CONCLUSIONS: The data from this study provide robust evidence that supports the efficacy of midday bright light therapy for bipolar depression. PMID: 28969438 [PubMed - as supplied by publisher]
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
Authors: Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, de Wit H, Wijkhuijs AJM, Colombo C, Drexhage HA Abstract BACKGROUND: The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light therapy (LT) prompt a rapid antidepressant response and can provide a model treatment to study predictors of response. METHODS: We studied at baseline 15 imm...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Publication date: March 2017 Source:European Psychiatry, Volume 41 Author(s): P. Canali, S. Casarotto, M. Rosanova, G. Sferrazza-Papa, A.G. Casali, O. Gosseries, M. Massimini, E. Smeraldi, C. Colombo, F. Benedetti When directly perturbed in healthy subjects, premotor cortical areas generate electrical oscillations in the beta range (20–40Hz). In schizophrenia, major depressive disorder and bipolar disorder (BD), these oscillations are markedly reduced, in terms of amplitude and frequency. However, it still remains unclear whether these abnormalities can be modulated over time, or if they can be still observed after ...
Source: European Psychiatry - Category: Psychiatry Source Type: research
Authors: Canali P, Casarotto S, Rosanova M, Sferrazza-Papa G, Casali AG, Gosseries O, Massimini M, Smeraldi E, Colombo C, Benedetti F Abstract When directly perturbed in healthy subjects, premotor cortical areas generate electrical oscillations in the beta range (20-40Hz). In schizophrenia, major depressive disorder and bipolar disorder (BD), these oscillations are markedly reduced, in terms of amplitude and frequency. However, it still remains unclear whether these abnormalities can be modulated over time, or if they can be still observed after treatment. Here, we employed transcranial magnetic stimulation (TMS) c...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
James Phelps’ new book, A Spectrum Approach to Mood Disorders: Not Fully Bipolar But Not Unipolar—Practical Management, is written for professionals, not laymen. I have some familiarity with bipolar disorder and its causes, symptoms, and treatments. However, I am not a professional and this book often goes beyond my ability to comprehend. Dr. Phelps has been treating patients and studying and writing about mood disorders for over 25 years, but he makes assumptions that the reader has a higher level of experience or training, and it makes this book difficult for amateurs to fully appreciate. The basic premise of...
Source: Psych Central - Category: Psychiatry Authors: Tags: Antidepressants Anxiety Attention Deficit Disorder Bipolar Book Reviews Borderline Personality Depression Disorders General Mood Stabilizers Postpartum Depression Professional Psychiatry Psychological Assessment Psychology PT Source Type: news
Bipolar disorder is one of the most difficult illnesses to treat because by addressing the depression part of the illness, you can inadvertently trigger mania or hypomania. Even in Bipolar II, where the hypomania is less destabilizing than the often-psychotic manic episodes of Bipolar I, persons often experience from a debilitating depression that can’t be lifted by mood stabilizers and antipsychotics. Antidepressants, though, can cause a person with bipolar to cycle between hypomania and depression. I have worked with psychiatrists who were too afraid of cycling to risk using antidepressants for bipolar patients. Th...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Mania Mental Health and Wellness Self-Help Sleep Antidepressant Antipsychotic Bipolar Disorder Depression Hypomania Mood Disorder Mood Stabilizers Rapid Cycling Sleep Deprivation Sleep Hygiene Source Type: blogs
This study examined whether this discrepancy could predict response to chronotherapeutics in bipolar depression.
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research
Abstract Growth factors involved in neurogenesis and neuroplasticity could play a role in biological processes that drive depression recovery. Combined total sleep deprivation and morning light therapy (TSD + LT) can acutely reverse depressive symptoms, thus allowing to investigate the neurobiological correlates of antidepressant response. We tested if changes on plasma levels of Brain Derived Neurotrophic Factor (BDNF), S100 calcium binding protein B (S100-B), Stem Cell Factor (SCF), Insulin-like Growth Factor-Binding Protein 2 (IGFBP-2), Epidermal Growth Factor (EGF), Platelet-Derived Growth Factor-BB ...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
Light therapy (LT) has been widely used in the treatment of seasonal affective disorder. Recently some evidence indicated that LT may play a role in bipolar depression, either as monotherapy or in combination with total sleep deprivation (TSD). However, the studies examining the treatment effect of LT in bipolar depression resulted in inconsistent findings. To clarify the role of LT in the disorder, we conducted a meta-analysis to compare the efficacy of LT in the treatment of bipolar depression.
Source: European Neuropsychopharmacology - Category: Psychiatry & Psychology Authors: Source Type: research
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