Immunohistochemical analysis of nestin, CD34 and TGF β3 in facial tissue of children with complete unilateral and bilateral cleft lip and palate.

CONCLUSION: Expression of nestin in complete unilateral and bilateral cleft lip and palate affected soft tissue indicates a potential increase of tissue regeneration. CD34 positive oral mucosa cells suggest increased angiogenesis, while the sporadic expression of TGFβ3 indicates an insignificant role in the maintenance and growth of cleft affected oral mucosa stem or progenitor cells. Nevertheless, scarce expression of TGFβ3 suggests a role in cleft morphopathogenesis. PMID: 28386053 [PubMed - in process]
Source: Stomatologija - Category: Dentistry Tags: Stomatologija Source Type: research