Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosino-philic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene.

Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosino-philic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene. Acta Derm Venereol. 2017 Apr 04;: Authors: García-Martínez P, Sitjas D, Llistosella E, Espinet B, Rodríguez-Rivera M, Hernandez-Muñoz M, Gallardo F, Pujol RM Abstract is missing (Short communication). PMID: 28374041 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Leukemia, Published online: 14 November 2019; doi:10.1038/s41375-019-0629-zHypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms
Source: Leukemia - Category: Hematology Authors: Source Type: research
AbstractHematologic malignancies include several lymphoproliferative and myeloproliferative disorders, many of which are frequently encountered in current health care settings. These malignancies frequently affect the gastrointestinal (GI) tract, either by secondary extranodal or extramedullary extension to the GI tract, or as a primary process arising in the GI tract. In fact, the GI tract may represent the most common extranodal site of involvement in many of them, such as lymphoma. Furthermore, in the current era of improved cancer treatment and advanced transplant procedures with increased survival, it has been quite c...
Source: Abdominal Imaging - Category: Radiology Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01348
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Leukemia, Published online: 07 November 2019; doi:10.1038/s41375-019-0616-4Reply to: Second primary malignancies in myeloproliferative neoplasms and the role of aspirin
Source: Leukemia - Category: Hematology Authors: Source Type: research
The objective of this article is to provide an overview of published evidence addressing the key question of the mechanisms underlying ruxolitinib-induced immunosuppression.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Condition:   Myelofibrosis Intervention:   Sponsor:   Fondazione per la Ricerca Ospedale Maggiore Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Background: Myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are characterized by excessive production of blood cells. Treatment of MPNs patients has an important effect thereby reducing morbidity and mortality.Objective: To evaluate the effect of cytoreductive treatment on some hematological and biochemical parameters in MPNs patients treated at a hemato-oncology Centre in Erbil, Iraq.Methods: A total of 185 patients diagnosed with PV, ET, and PMF (111 males and 74 females with a mean age of 50.8 ±3.2 years, range: 46-73) were assign...
Source: African Health Sciences - Category: African Health Source Type: research
Authors: Kurtovic-Kozaric A, Islamagic E, Komic H, Bilalovic N, Eminovic I, Burekovic A, Uzunovic A, Kurtovic S Abstract The identification of mutually exclusive somatic mutations shared among myeloproliferative neoplasm (MPN) subtypes has provided a powerful tool for studying disease evolution. Clinical features, gene mutations, and survival over 18 years were analyzed in MPN patients. One hundred thirty-eight MPN patients were subcategorized according to MPN subtypes: essential thrombocythemia (ET, n = 41), polycythemia vera (PV, n = 56), primary myelofibrosis (PMF, n = 10), and MPN unclassified (MPN-U, n = ...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
The correlation of gene polymorphismsrs4025935 (large deletion),rs1695 (313A>G),rs71748309 (large deletion), andrs1800566 (609C>T) ofGSTM1,GSTT1, andNQO1 genes encoding glutathione-S-transferases (GST) M1, P1, and T1 and NADPH-quinone oxidoreductase with the risk of development of classical Ph-negative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, and primary myelofibrosis) was studied in the Caucasian ethnicity population of Vyatka region of the Russian Federation. It was found thatNQO1*609T allele,NQO1*609T genotypes, and homozygous carriage of a deletion (null) allele ofGSTT1 gene are...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
frey J. Babon Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cytokine exposure. Activating mutations of JAKs are causative for a number of leukemias, lymphomas, and myeloproliferative diseases. In particular, the JAK2V617F mutant is found in most human cases of polycythemia vera, a disease characterized by over-production of erythrocytes. The V617F mutation is found in the pseudokinase domain of JAK2 and it leads to cytokine-independent activation of the kinase, as does the orthologous mutation in other JAK-family members. The mechanism whe...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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