Drugmaker GSK Recalling Nearly 600,000 Asthma Inhalers in U.S. Drugmaker GSK Recalling Nearly 600,000 Asthma Inhalers in U.S.

GSK Plc is voluntarily recalling more than 593,000 Ventolin asthma inhalers from U.S. hospitals, pharmacies, retailers and wholesalers due to a defect that may cause them to deliver fewer doses of the medicine than indicated, the British drugmaker said on Tuesday.News Alerts
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pulmonary Medicine News Alert Source Type: news

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AbstractPurpose of ReviewCharcot-Leyden crystals (CLCs), slender bipyramidal hexagonal crystals, were first described by Jean-Martin Charcot in 1853, predating Paul Ehrlich ’s “discovery” of eosinophils by 26 years. To date, CLCs are known as a classical hallmark of eosinophilic inflammation. CLC protein expresses palmitate cleaving lysophospholipase activity and is a member of the family of S-type lectins, galectin-10. We summarize current knowledge regarding t he pathological observations of CLCs and their mechanism of generation focusing on eosinophil cell death.Recent FindingsThe presence of CLCs...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
We read with great interest the recent review on epigenetic inheritance in patients with allergic disease.1 The evidence for epigenetic transmission of allergic disease across generations in human subjects is discussed by the authors. We have a few further comments, and some errors in the presented table need to be corrected.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
She and her husband identified an antibody that triggers wheezing and rashes. Monitoring it can help prevent and remedy allergic reactions.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Allergies Ishizaka, Teruko (1926-2019) Deaths (Obituaries) Asthma Hay Fever Ishizaka, Kimishige (1925-2018) Tokyo (Japan) La Jolla (Calif) Doctors Source Type: news
Publication date: Available online 13 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Pasquale Comberiati, Katie McCormack, Jonathan Malka-Rais, Joseph D. SpahnBackgroundMepolizumab is an anti–IL-5 antibody approved for the treatment of severe eosinophilic asthma. However, the prevalence of patients with severe asthma eligible for mepolizumab remains unknown, especially among children.ObjectiveTo determine, in a population of patients with severe asthma from a tertiary referral center, the proportion of patients with an eosinophilic phenotype who would be eligible for mepolizuma...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 13 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Evgenia Papathanasiou, Petros Bakakos, Georgios Hillas, Polyxeni Ntontsi, Myrto Blizou, Konstantinos Kostikas, Nikolaos Koulouris, Spyros Papiris, Stelios Loukides
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Bacterial lysate, a cocktail of 21 microbial species commonly used in Europe, purportedly decreases asthma and wheezing in children and specialists are taking notice.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news
Abstract KEY POINTS: Experimental maternal allergic asthma in sheep provides an experimental model in which to test impacts on progeny Fetuses from allergic asthmatic ewes had fewer surfactant-producing cells in lungs A greater proportion of lymphocytes from thymus were CD44 positive in fetuses from allergic asthmatic ewes than controls These changes to fetal development might contribute to poor neonatal lung function and increased risk of allergy seen in offspring of pregnancies complicated by asthma ABSTRACT: Asthma is prevalent in pregnancy and increases the risk of disease in offspring, including neonatal resp...
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
DiGeorge syndrome (DGS) is a primary immunodeficiency characterized by various degrees of T-cell deficiency. In partial DGS (pDGS), other risk factors could predispose to recurrent infections, autoimmunity, and allergy. The aim of this study was to assess the effect of different factors in the development of infections, autoimmunity, and/or allergy in patients with pDGS. We studied 467 pDGS patients in follow-up at Great Ormond Street Hospital. Using a multivariate approach, we observed that palatal anomalies represent a risk factor for the development of recurrent otitis media with effusion. Gastroesophageal reflux/dyspha...
Source: Blood - Category: Hematology Authors: Tags: Pediatric Hematology, Immunobiology and Immunotherapy Source Type: research
There remains an unmet need for effective, well-tolerated therapeutic options in paediatric patients with not fully controlled asthma, for whom safety is of paramount importance. Data were pooled from five randomised, double-blind, placebo-controlled studies evaluating tiotropium 5 or 2.5 µg versus placebo add-on therapy in patients with symptomatic asthma aged 1–17 years. Analysis included adverse events (AEs) and serious AEs (SAEs) reported throughout and for 30 days following treatment. Of 1691 patients treated, 1119 received tiotropium. Reporting of AEs was low and comparable across all group...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Asthma Source Type: research
Conclusion: Despite the limitations of this retrospective study, the association between LTRAs and ANCA antibodies elucidates the mechanism by which innate immunity is directly involved in tolerance breakdown and autoantibodies production. Validation of our results with targeted studies could clarify the differences between ANCA-positive and ANCA-negative patients with important consequences on the use of some drug classes in the treatment of EGPA and asthmatic subjects.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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