Impact of diabetes on outcome in critical limb ischemia with tissue loss: a large-scaled routine data analysis

Patients with diabetes concomitant to critical limb ischemia (CLI) represent a sub-group at particular risk. Objective of this analysis is to evaluate the actual impact of diabetes on treatment, outcome, and c...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research

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Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25% of patients. PDN is characterized by neuropathic pain and small-fiber degeneration, accompanied by dorsal root ganglion (DRG) nociceptor hyperexcitability and loss of their axons within the skin. The molecular mechanisms underlying DRG nociceptor hyperexcitability and small-fiber degeneration in PDN are unknown. To delineate the molecular mechanisms behind nociceptor hyperexcitability and small-fiber degeneration, it becomes important to uniquely identify changes in the nociceptor population from within the heterogeneous populatio...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Pain is a tremendous health care burden associated with prediabetes and diabetes. However, not everyone with prediabetes or diabetes develops pain and the factors that increase susceptibility to painful neuropathy remain elusive. The epidermis is innervated by both peptidergic and nonpeptidergic axons and our studies in mice reveal that mechanical allodynia induced by consuming a high fat diet increases peptidergic epidermal axons. We hypothesize that patients with prediabetes and painful neuropathy have an abnormal proportion of epidermal peptidergic axons.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
The current study assessed associations of clinical characteristics and all-cause mortality among a cohort of Veterans initiating pain services. Analyses were also stratified by age to examine potential variations. Demographic (male, age), medical comorbidities (diabetes, myocardial infarction, chronic pulmonary conditions, cancer, renal disease, liver disease), pain characteristics (pain intensity, opioid analgesic prescription), and mental health characteristics (depression, opioid use disorder, opioid poisoning/suicide attempts) were extracted from Veterans Health Administration records.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
NYX-2925, a novel small-molecule modulator of the N-methyl-D-aspartate receptor (NMDAR), was evaluated in a randomized, double-blind, placebo-controlled study, in which 302 subjects with painful DPN received daily oral doses of placebo or NYX-2925 at 10mg, 50mg, or 200mg for four weeks (NCT03219320). This first-in-patient study was conducted across 35 U.S.-based sites and subjects were randomized in a 1:1:1:1 ratio. Average pain intensity was collected using the 11-point Numerical Rating Scale and subjects were assessed for randomization eligibility using a proprietary algorithm employed to improve assay sensitivity.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
According to the Centers for Disease Control and Prevention, approximately 50 percent of the 30 million Americans with diabetes suffer from diabetic neuropathy, which results in numbness and tingling in one's limbs. As the disease progresses, 50 percent of the diabetic neuropathy patients develop neuropathic pain as a result of damage to the peripheral nerves which can produce debilitating limb pain. Despite an improved understanding of the molecular mechanisms of nociception, most clinical trials still use self-reported measures of pain as their primary efficacy endpoint.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Publication date: Available online 20 March 2019Source: Food Research InternationalAuthor(s): Erika V. Mejía, Karla A. Batista, Juan Jose A. Fernández, Kátia F. FernandesAbstractThe present study was undertaken to examine the antidiabetic potential of naturally occurring peptides and hydrolysate fractions from easy-to-cook (ETC) and hard-to-cook (HTC) beans. All fractions were tested regarding their in vitro inhibitory activities against α-amylase and α-glucosidase as well as in vivo anti-hyperglycemic and hypoglycemic effects. Results evidenced that the peptide fractions with the lowest molecular weight (
Source: Food Research International - Category: Food Science Source Type: research
"Encephalopathy Only Stroke Codes" (EoSC) Rarely Result in Stroke as Final Diagnosis. Neurol Res Int. 2019;2019:2105670 Authors: Chen PM, Meyer DM, Claycomb R, Agrawal K, Meyer BC Abstract Stroke codes prompted by isolated encephalopathy often result in nonstroke final diagnoses but require intensive stroke center resources. We assessed the likelihood of "Encephalopathy only Stroke Codes (EoSC)" resulting in a true stroke (EoSC CVA+) final diagnosis. 3860 patients were analyzed in a prospective stroke code registry from 2004 to 2016. EoSC was defined using a standard and an explorat...
Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Chu Chu, Tuo Li, Hans Albert Pedersen, Kenneth T. Kongstad, Jizhong Yan, Dan StaerkAbstractType 2 diabetes is a chronic metabolic disorder affecting millions of people worldwide, and new drug leads are urgently needed. The dried stem of Dendrobium officinale is used in China to alleviate the symptoms of diabetes, but investigations of its bioactive components have been limited. We have applied a simple, fast, and effective method, combining triple high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibit...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
In this study, silica-alumina (SA) is used as an environmentally-safe and effective adsorbent for removing MF from aqueous solution by adsorption. Adsorption experiments were employed studying the effect of pH, contact time, and MF initial concentration to investigate both the removal efficiency of MF and the interaction mechanism. A set of characterization techniques, such as SEM, BET, FTIR, TPD-MS, and zeta potential were performed before and after adsorption experiments to confirm the role of structural morphology, surface area, porosity, surface acidity and charge in adsorption. The characterization analysis showed tha...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
[IPS] Canberra, Philadelphia and Manchester -Depression is often distinguished from other non-communicable diseases or NCDs (e.g., cancer, diabetes, cardio-vascular diseases, hypertension) because of the stigma attached to it. Among other consequences, those suffering from depression are often denied access to medical care. Indeed, the latter is an outcome of interaction between supply of and demand for medical care. On the provider side, stigmatizing attitudes by service providers are identified as a barrier to access. On the demand side, stigma and
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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