Effects of the SGLT2 inhibitor dapagliflozin on HDL cholesterol, particle size, and cholesterol efflux capacity in patients with type 2 diabetes: a randomized placebo-controlled trial

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) reduce glucose levels, body weight, and blood pressure, possibly resulting in cardiovascular protection. In phase III trials, SGLT2i were shown to increase H...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research

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Conclusion: The TEMD Obesity Study shows that obesity is a major determinant of the poor metabolic control in patients with type 2 diabetes. These results underline the importance of prevention and management of obesity to improve health care in patients with type 2 diabetes. Also, the results point out the independent sociodemographic and clinical associates of obesity, which should be the prior targets to overcome, in the national fight with obesity.Obes Facts 2019;12:167 –178
Source: Obesity Facts - Category: Eating Disorders & Weight Management Source Type: research
CONCLUSION: The genotypic distribution of Chr-11 tRNA-Lys-CUU in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition. PMID: 30882233 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
ConclusionThe serum levels of OXA and leptin are altered and significantly correlate to increase in the number of metabolic determinants in type 2 diabetes mellitus patients.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
Experts have issued a new set of guidelines on the best ways to prevent first heart attacks, strokes and heart failure — and for the first time, they focus squarely on the patient. The new guidelines recognize how doctors can support people to not only address their medical risk factors, but also to change their behaviors and lifestyles in order to reduce their risk. The latest revisions to the guidelines, issued by the American College of Cardiology (ACC) and the American Heart Association (AHA), were announced at the annual meeting of the ACC. They are intended to help doctors figure out a patient’s risk of h...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Heart Disease Source Type: news
(CNN) — If you’re a healthy older adult looking for ways to reduce your risk of heart attack and stroke, don’t turn to that age-old standby: daily low-dose aspirin. It’s no longer recommended as a preventative for older adults who don’t have a high risk or existing heart disease, according to guidelines announced Sunday by the American College of Cardiology and the American Heart Association. “For the most part, we are now much better at treating risk factors such as hypertension, diabetes and especially high cholesterol,” said North Carolina cardiologist Dr. Kevin Campbell, who wa...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News aspirin CNN Source Type: news
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Much of the cardiovascular disease burden and mortality can be traced back to four adverse health behaviors (smoking, poor diet, elevated body mass index, sedentary lifestyle) and three major risk factors (hypercholesterolemia, hypertension, diabetes). Ideal cardiovascular health defined as having all seven factors at goal is very rare among US adults. It is estimated that 87% of middle-aged US adults and 95% of individuals ≥60 years old meet ≤4 of these health metrics.1 Detailed guidelines are available that discuss cardiovascular risk assessment, lifestyle management, and treatment of individual r...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
The headlines are once again filled with advice to reduce egg and cholesterol consumption based on a study that found an association of egg and cholesterol consumption with increased risk for cardiovascular events. Sounds scary and persuasive, doesn’t it? After all, nearly 30,000 people were tracked over 17 years and the authors authoritatively declare that this proves that eggs and cholesterol are risk factors for heart disease. There are several problems with this assessment. It is emblematic of the studies that confuse people, yield wildly conflicting conclusions, are used to craft absurd and ineffective dietary g...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates cholesterol eggs grain-free saturated fat undoctored wheat belly Source Type: blogs
Publication date: Available online 14 March 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Emanuela Mensà, Angelica Giuliani, Giulia Matacchione, Felicia Gurău, Anna Rita Bonfigli, Fabio Romagnoli, Maria De Luca, Jacopo Sabbatinelli, Fabiola OlivieriAbstractTo evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR‐146a levels, 188 healthy subjects (CTR) aged 20-104 years and 144 type-2 diabetic patients (T2DM), aged 40‐80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research
ConclusionThere is no apparent relation between plasma TSH levels in the normal range and incident T2DM in patients at high cardiovascular risk.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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