Minocycline inhibits the Candida albicans budded-to-hyphal-form transition and biofilm formation.

Minocycline inhibits the Candida albicans budded-to-hyphal-form transition and biofilm formation.
Jpn J Infect Dis. 2017 Mar 28;:
Authors: Kurakado S, Takatori K, Sugita T
Abstract
Candida albicans frequently causes bloodstream infections; the budded-to-hyphal-form transition (BHT) and biofilm formation are major contributors to virulence. In a survey of antibacterial compounds that inhibit C. albicans BHT, we found that the tetracycline derivative minocycline inhibited BHT and subsequent biofilm formation. Minocycline downregulates expression of the hypha-specific genes HWP1 and ECE1, and the adhesion factor gene ALS3 of C. albicans. In addition, minocycline decreases cell surface hydrophobicity and the extracellular β-glucan level in biofilms. Minocycline has been widely used for catheter antibiotic lock therapy in efforts to prevent bacterial infection; the compound might also be prophylactically effective against Candida infection.
PMID: 28367877 [PubMed - as supplied by publisher]

Source: Japanese Journal of Infectious Diseases - March 28, 2017 Category: Infectious Diseases Authors: Kurakado S, Takatori K, Sugita T Tags: Jpn J Infect Dis Source Type: research