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Lyme Disease Is on the Rise

Title: Lyme Disease Is on the RiseCategory: Doctor's&Expert's views on SymptomsCreated: 4/29/2000 12:00:00 AMLast Editorial Review: 3/27/2017 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news

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(University of Utah Health) Scientists at University of Utah Health believe they identified a mechanism that activates T cells, a key component of the immune system, which could explain the elusive link between a tick bite and persistent Lyme arthritis. The results are published online in the February 5th issue of The Journal of Immunology.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Lyme arthritis: Bystander-activated T cells contribute to Lyme arthritis, Published online: 01 February 2018; doi:10.1038/nrrheum.2018.12Lyme arthritis: Bystander-activated T cells contribute to Lyme arthritis
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
In the present study, we sought to evaluate the feasibility of targeting vascular adhesion protein-1 (VAP-1) by positron emission tomography (PET) for the longitudinal quantitative assessment of Borrelia burgdorf...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination. The ticks were firmly latched on to the skin and careful removal prevented incarceration of the mouth parts. Rickettsial diseases that were believed to have disappeared from India are reemerging and their presence has recently been documented in at least 11 states in the country. Among vector borne diseases, the most common, Lyme disease, also known ...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
This report highlights the continuing public health challenge of Lyme disease in states with high incidence and demonstrates its emergence in neighboring states that previously experienced few cases. Educational efforts should be directed accordingly to facilitate prevention, early diagnosis, and appropriate treatment. As Lyme disease emerges in neighboring states, clinical suspicion of Lyme disease in a patient should be based on local experience rather than incidence cutoffs used for surveillance purposes. A diagnosis of Lyme disease should be considered in patients with compatible clinical signs and a history of potenti...
Source: MMWR Surveill Summ - Category: Epidemiology Authors: Tags: MMWR Surveill Summ Source Type: research
Abstract The spirochete bacterium Borrelia burgdorferisensu lato is the causative agent of Lyme disease, the most common vector-borne disease in Europe and the United States. The spirochetes can be transmitted to humans via ticks, and then spread to different tissues, leading to arthritis, carditis and neuroborreliosis. Although antibiotics have commonly been used to treat infected individuals, some treated patients do not respond to antibiotics and experience persistent, long-term arthritis. Thus, there is a need to investigate alternative therapeutics against Lyme disease. The spirochete bacterium colonization i...
Source: Microbiology - Category: Microbiology Authors: Tags: Microbiology Source Type: research
is the most common tick-borne illness in the USA and Europe. Pathogens involved are Borrelia burgdorferi in the USA and B. afzelii and B. garinii in Europe. The characteristic rash of erythema migrans occurs in approximately 75% of patients. Neurological disease, including facial palsy, meningoencephalitis, aseptic meningitis and polyradiculopathy, occurs in 10 –15%. Cardiac disease, primarily manifest as heart block, is seen in 1–2%. Arthritis is seen as a late complication in about 30%.
Source: Medicine - Category: Internal Medicine Authors: Tags: Bacterial infections Source Type: research
In this study, we show that mAb blockade revealed a unique role for IFN-β in Lyme arthritis development in B6.C3-Bbaa1 mice. Genetic control of IFN-β expression was also identified in bone marrow-derived macrophages stimulated with B. burgdorferi, and it was responsible for feed-forward amplification of IFN-stimulated genes. Reciprocal radiation chimeras between B6.C3-Bbaa1 and C57BL/6 mice revealed that arthritis is initiated by radiation-sensitive cells, but orchestrated by radiation-resistant components of joint tissue. Advanced congenic lines were developed to reduce the physical size of the Bbaa1 interval, a...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
We report an atypical case of European LCLB, suggesting that ACA is not the only possible presentation of LCLB. The diagnosis of ACA is often clinically missed for months or years, and may be mistaken at the inflammation phase for vascular disorders, erysipelas or bursitis/arthritis, and at the atrophic phase for lichen sclerosus atrophicus, morphoea or anetoderma. To our knowledge, no such tumorous LCLB has previously been described.
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Case Report: Clinical and Diagnostic Source Type: research
Publication date: October 2017 Source:Microbial Pathogenesis, Volume 111 Author(s): Hua Zhao, Aihua Liu, Yuhui Cui, Zhang Liang, Bingxue Li, Fukai Bao Lyme neuroborreliosis is a nervous system infectious disease caused by Borrelia burgdorferi (B. burgdorferi). It has been demonstrated that cytokines induced by B. burgdorferi are related to Lyme neuroborreliosis. Microglia is known as a key player in the immune responses that occur within the central nervous system. In response to inflammation, it will be activated and generate cytokines and chemokines. Experiments in vitro cells have showed that B. Burgdorf...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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