Paratek shares soar as antibiotic passes late-stage hurdle

Shares of Paratek Pharmaceuticals jumped in after-hours trading Monday after the Boston-based biotech said that its lead antibiotic drug had performed well in a Phase 3 study involving patients with hospital-acquired pneumonia. The news comes a week after reporting positive data from a late-stage trial of an acne treatment. Paratek (Nasdaq: PRTK) said the 774-patient study had showed that omadacycline was nearly as effective as another common antibiotic, moxifloxacin, in helping patients reduce…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news

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Authors: Conti P, Gallenga CE, Tetè G, Caraffa A, Ronconi G, Younes A, Toniato E, Ross R, Kritas SK Abstract SARS-CoV-2, also referred to as CoV-19, is an RNA virus which can cause severe acute respiratory diseases (COVID-19), with serious infection of the lower respiratory tract followed by bronchitis, pneumonia and fibrosis. The severity of the disease depends on the efficiency of the immune system which, if it is weak, cannot stem the infection and its symptoms. The new CoV-19 spreads in the population at a rate of 0.8-3% more than normal flu and mostly affects men, since immune genes are more expressed o...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Purpose of review Although pneumonia, either community or hospital-acquired, is the most frequent severe respiratory infection, it is an infection difficult to diagnose. At present, the diagnosis of pneumonia relies on a combination of clinical, radiologic, and microbiologic criteria. However, these criteria are far from perfect leading to uncertainty in the diagnosis, risk stratification, and choice of antibiotic therapy. Biomarkers have been used to bring additional information in this setting. Recent findings The aim of this review is to provide a clear overview of the current evidence for biomarkers to distinguish...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research
Purpose of review Pneumonia is the main global cause of sepsis, and has been associated with high morbidity and high short and long-term mortality rates. As it may be caused by a wide spectrum of microorganisms, microbial diagnosis is challenging and the choice of adequate therapy remains an important problem. This review focuses on recently published studies of microbiological diagnostic tests and clinical assessments for pneumonia, including community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia. Recent findings Over the past decade, the microbiological diagnosis of pneumonia ...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research
Purpose of review Although most patients with community-acquired pneumonia (CAP) are appropriately treated with narrow-spectrum antibiotics, predicting which patients require coverage of drug-resistant pathogens (DRP) remains a challenge. The 2019 American Thoracic Society/Infectious Diseases Society of America CAP guidelines endorse using locally validated prediction models for DRP. Here we review risk factors for DRP and provide a summary of available risk prediction models. Recent findings Both inadequate initial empiric spectrum as well as unnecessary broad-spectrum antibiotic use are associated with poor outcomes...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research
We described a 15-year-old female with a history of six months of acne-like facial and peri-auricular lesions. She had received the conventional treatment for acne (antibiotics + topical corticosteroid) with no response. She also had a history of chronic coughs which always diagnosed and treated as sinusitis. In addition, she had a history of frequent dysuria which always diagnosed and treated as urinary tract infection. Given the history, with suspicion of a multi-systemic disease such as vasculitis; we performed some diagnostic laboratory and radiologic tests in order to rule out the possible etiologies. The results show...
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
François Chassagne1†, Xinyi Huang1†, James T. Lyles1 and Cassandra L. Quave1,2* 1Center for the Study of Human Health, Emory University, Atlanta, GA, United States 2Department of Dermatology, Emory University, Atlanta, GA, United States In the search for new therapeutic solutions to address an increasing number of multidrug-resistant bacterial pathogens, secondary metabolites from plants have proven to be a rich source of antimicrobial compounds. Ginkgo biloba, a tree native to China, has been spread around the world as an ornamental tree. Its seeds have been used as snacks and medical mater...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
The new Undoctored book is scheduled for release this coming May 9th, 2017, a book that shows how you can be freed from the bonds of a predatory, profit-seeking healthcare system.  Here’s a bit more from the book, now available in pre-release.   Undoctored: An excerpt Unquestionably, there are situations in which doctoring and the healthcare system are needed. If you are bleeding, injured, or struggling to breathe with pneumonia, some old-fashioned suturing, bone-setting, or antibiotics can still do the trick. Nobody around here is going to replace their own hip joint or treat a urinary tract infection with...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat-Free Lifestyle autoimmune diabetes gluten grains hypertension Inflammation metabolic undoctored Weight Loss wheat belly Source Type: blogs
Kira M. Newman As virtues go, patience is a quiet one. It's often exhibited behind closed doors, not on a public stage: A father telling a third bedtime story to his son, a dancer waiting for her injury to heal. In public, it's the impatient ones who grab all our attention: drivers honking in traffic, grumbling customers in slow-moving lines. We have epic movies exalting the virtues of courage and compassion, but a movie about patience might be a bit of a snoozer. Yet patience is essential to daily life -- and might be key to a happy one. Having patience means being able to wait calmly in the face of frustration or adversi...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Introduction Minocycline is an effective treatment for inflammatory cutaneous conditions, such as acne vulgaris and rosacea, infectious conditions and has recently been investigated for its neuroprotective properties. However, treatment with minocycline can induce iatrogenic pigmentation, affecting both the skin and other organs. Recognition of these changes may avoid unnecessary investigations. This image case report aims to remind clinicians of this often-persistent side effect of minocycline. Case A 73-year-old man attended the dermatology outpatient clinic with a 20-year history of progressive swelling of the nose, ass...
Source: Postgraduate Medical Journal - Category: Journals (General) Authors: Tags: Liver disease, Urology, Genetics, Immunology (including allergy), Drugs: infectious diseases, Movement disorders (other than Parkinsons), Stroke, Hypertension, Psychotic disorders (incl schizophrenia), Pneumonia (respiratory medicine), Connective tissue d Source Type: research
Publication date: Available online 30 May 2015 Source:Respiratory Medicine Case Reports Author(s): Sharon W. Hung , Scott Oh Acute eosinophilic pneumonia (AEP) can be a challenging diagnosis and is often initially misdiagnosed as one of the more common pneumonia syndromes such as acute respiratory distress syndrome. Early bronchoalveolar lavage (BAL) is critical in distinguishing the diagnosis to initiate proper management. The etiology of AEP is unknown, though many drugs have been implicated, including minocycline. Minocycline is commonly used for pneumonia, acute bronchitis, urinary tract infections, and acne and is l...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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