Why female fertility fades as you age

A new study, from the University of Montreal Hospital in Canada, has discovered that eggs in older women have the wrong number of chromosomes, a cause of infertility.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Xie D, Lu C, Zhu Y, Zhu S, Yang EJ, Jin X Abstract We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fragmentation index and infertility. Eighty cases of infertile males and 20 cases of normal males with children were divided into the infertility and control groups, respectively. Sperm DNA fragmentation index, conventional semen parameters, serum microelement cont...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
AbstractPurpose of ReviewMale pattern hair loss, mediated by dihydrotestosterone, is a common hair loss disorder, affecting over 50% of men over the age of 50. The 5- α reductase inhibitors, finasteride and dutasteride, are Food and Drug Administration-approved drugs for the treatment of this disorder. Several recent studies have reported adverse sexual and spermatogenic events among young men using 5-α reductase inhibitors, such as erectile dysfunction, decrea sed ejaculate volume, decreased libido, and infertility. In this review, we summarize and analyze the literature regarding the efficacy and safety of th...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
In conclusion, the results of the present study identified several mRNAs involved in sperm morphological development, which may aid in the understanding and treatment of infertility. PMID: 29901159 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Inflammatory cytokine profile of co‑cultivated primary cells from the endometrium of women with and without endometriosis. Mol Med Rep. 2018 Jun 06;: Authors: Luckow Invitti A, Schor E, Martins Parreira R, Kopelman A, Kamergorodsky G, Gonçalves GA, Batista Castello Girão MJ Abstract Endometriosis is a chronic gynecological disorder defined as the presence of endometrial tissue within extra-uterine sites. The primary symptoms are infertility and chronic pain. The inflammatory environment and aberrant immune responses in women with endometriosis may be directly associated with the initiat...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Conditions:   Implantation Failure;   Infertility, Female Interventions:   Other: FET according to ERA;   Other: FET according to standard protocol Sponsors:   Shady Grove Fertility Reproductive Science Center;   Igenomix Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we used CRISPR to construct an NPC1-/- zebrafish model, which faithfully reproduced the cardinal pathological features of this disease. In contrast to the wild type, the deletion of NPC1 alone caused significant hepatosplenomegaly, ataxia, Purkinje cell death, increased lipid storage, infertility and reduced body length and life span. Most of the NPC1-/- zebrafish died within the first month post fertilization, while the remaining specimens developed slower than the wild type and died before reaching eight months of age. Filipin-stained hepatocytes of the NPC1-/- zebrafish were clear, indicating abnormal acc...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Conclusions This study demonstrates that the use of ICSI for unexplained infertility achieved similar reproductive outcomes as male infertility cases, which are usually referred to ICSI. It also shows that the quality of semen did not positively affect ICSI outcomes.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Spermatogenesis is precisely controlled by complex gene expression programs and involves epigenetic reprogramming, including histone modification and DNA methylation. SET domain–containing 2 (SETD2) is the predominant histone methyltransferase catalyzing the trimethylation of histone H3 lysine 36 (H3K36me3) and plays key roles in embryonic stem cell differentiation and somatic cell development. However, its role in male germ cell development remains elusive. Here, we demonstrate an essential role of Setd2 for spermiogenesis, the final stage of spermatogenesis. Using RNA-seq, we found that, in postnatal mouse testes, ...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Developmental Biology Source Type: research
Condition:   Infertility Interventions:   Drug: Follicular phase corifollitropin alfa;   Drug: Luteal phase corifollitropin alfa Sponsor:   Institut Universitari Dexeus Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The use of pronuclear transfer to treat infertility must first be backed by evidence it can work in cases where parents seek to avoid mitochondrial mutations.
Source: The Scientist - Category: Science Tags: News & Opinion,Opinion Source Type: news
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