A case of contralateral breast cancer and skin cancer associated with NBN heterozygous pathogenic variant c.698_701delAACA

AbstractApproximately 39.6% of people will be diagnosed with cancer during their lifetime. Several factors including, lifestyle, environment and genetics may play a role in its development. Understanding these causes will greatly improve treatment methods, prevention, and survival rates of these patients. Our patient, who has a positive family history of cancer, presented with contralateral breast cancer and multiple skin malignancies. Genetic testing revealed a frameshift variant inNBN. This gene encodes the protein, nibrin, which is involved in maintaining genomic stability. Several reports have identified heterozygousNBN frameshift (c.2028delT, c.2097dupT, c.657-661delACAAA) and splice site variants (c.1397+delG) in patients with breast cancer. However, our report is the first to describe a heterozygous c.698_701delAACANBN variant in a patient with breast cancer. SinceNBN is involved in DNA integrity, loss of functional protein due to pathogenic variants significantly increases the risk of various cancers. Given the family and personal history of our patient, in connection with previous reports ofNBN pathogenic variants predisposition to cancer, this variant is predicted to be pathogenic and clinically significant.
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research