Vaccine Associated Paralytic Poliomyelitis Unmasking Common Variable Immunodeficiency.

Vaccine Associated Paralytic Poliomyelitis Unmasking Common Variable Immunodeficiency.
Indian Pediatr. 2017 Mar 15;54(3):241-242
Authors: Gomber S, Arora V, Dewan P
Abstract
BACKGROUND: Oral polio vaccine can rarely lead to Vaccine-associated paralytic poliomyelitis (VAPP).
CASE CHARACTERISTICS: A 2-year-old child with asymmetric paralysis of lower limbs following first booster of oral polio vaccine; type 2 Vaccine-derived poliovirus (VDPV) isolated. Subsequently, the child was diagnosed to have common variable immunodeficiency.
OUTCOME: Paralysis gradually improved on follow-up; monthly intravenous immunoglobulin therapy started for primary immunodeficiency.
MESSAGE: We need to evaluate children with VAPP for underlying immunodeficiency.
PMID: 28361789 [PubMed - in process]

Source: Indian Pediatrics - March 15, 2017 Category: Pediatrics Authors: Gomber S, Arora V, Dewan P Tags: Indian Pediatr Source Type: research