Fibrinogen and postpartum hemorrhage – Association or causality?

Publication date: Available online 1 April 2017 Source:Colombian Journal of Anesthesiology Author(s): David A. Rincón-Valenzuela, Juan Carlos Bocanegra, Jennifer Guevara Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide, accounting for one in four maternal deaths. Despite efforts in public health policy, the incidence of massive PPH has increased in recent years even in first world countries. In Colombia, PPH is the second leading cause of maternal death. Multiple observational studies have provided evidence about the association between the concentration levels of fibrinogen in blood plasma and the severity of PPH, proposing the systematic use of fibrinogen concentrates as a prophylactic or therapeutic measure in patients with obstetric hemorrhage. However, the statistical relationship demonstrated in such studies should not necessarily be interpreted as a cause-effect relationship. Traditionally, we have used the criteria postulated by Sir Arthur Bradford Hill to establish a causal relationship. Therefore, the most pragmatic way to evaluate a possible causal relationship is through a randomized placebo-controlled experiment. Experiments of this kind available to date have methodological deficiencies or have been criticized for internal validity. As a result, the statistical relationship (association) between low levels of fibrinogen and PPH cannot be certainly interpreted as a cause-effect relationship and the use of fibrinogen concentrate...
Source: Colombian Journal of Anesthesiology - Category: Anesthesiology Source Type: research

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ConclusionThis study suggests that the post-auricular approach is a feasible and less time consuming route for round window drug delivery experiments in Wistar albino rats. Recognition of anatomical landmarks, particularly the facial nerve is the key to surgery.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Anyone have any good stories?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
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Source: NeuroImage - Category: Neuroscience Source Type: research
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Source: Indian Journal of Dental Research - Category: Dentistry Authors: Source Type: research
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Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
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Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
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Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
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