Effects of Esophageal Acidification on Troublesome Symptoms: An Approach to Characterize True Acid GERD in Dysphagic Neonates

AbstractTo quantify and compare maximal extent (height) of acid reflux events (AREs) on symptom generation in dysphagic neonates. Dysphagic neonates (N = 53), born at 30 ± 5.3 weeks gestation, underwent 24-hour pH-impedance study for the evaluation of troublesome symptoms purported to be due to gastroesophageal reflux disease (GERD). AREs (pH 4  s) detected by impedance (Z) were categorized by maximal extent as refluxate reaching distal (Z6, Z5), middle (Z4, Z3), or proximal (Z2, Z1) impedance channels. AREs reaching the pH sensor only were categorized as distal. Symptom correlation (%, symptom index, symptom sensitivity index, and sympto m associated probability) and temporal characteristics (clearance times) of AREs were analyzed using linear mixed and GEE models comparing height categories presented as mean ± SEM, median (IQR), and OR (95% CI). Of the 2003 AREs, 1) distal extent AREs (n = 1642) had increased frequency (p 
Source: Dysphagia - Category: Speech Therapy Source Type: research

Related Links:

Aspiration is a syndrome with variable respiratory manifestations that span acute, life-threatening illnesses, such as acute respiratory distress syndrome, to chronic, sometimes insidious, respiratory disorders such as aspiration bronchiolitis. Diagnostic testing is limited by the insensitivity of histologic testing, and although gastric biomarkers for aspiration are increasingly available, none have been clinically validated. The leading mechanism for microaspiration is thought to be gastroesophageal reflux disease, largely driven by the increased prevalence of gastroesophageal reflux across a variety of respiratory disor...
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Review Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: AGA Abstracts Source Type: research
Conclusion This study showed that the presence of GERD and/or nasal symptoms is associated with an increase in bronchitis symptoms. Careful assessment of extrapulmonary comorbidities is necessary in the evaluation of bronchitis symptoms in COPD patients.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
I’ve always thought it sounded counterintuitive to use an acid to alleviate indigestion, but the number of times I’ve heard people treat their symptoms of heartburn with apple cider vinegar is too large to count. So, I decided to look into whether this strategy works, and to do some investigation about the idea behind its use. To my surprise, there is no research published in medical journals that addresses using raw apple cider vinegar to treat heartburn, despite widespread use and recommendations from blogs and websites. What is heartburn? Heartburn is most commonly caused by stomach acid contents traveling u...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Digestive Disorders Folk remedies Health Source Type: blogs
Publication date: Available online 27 March 2018 Source:Respiratory Physiology & Neurobiology Author(s): Martin Duricek, Lenka Nosakova, Tomas Zatko, Renata Pecova, Rudolf Hyrdel, Peter Banovcin The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the relationship between cough reflex sensitivity (CRS) and esophageal sensitivity to acid. We evaluated CRS to cap...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Gastroesophageal reflux disease (GERD) or Gastro-Oesophageal Reflux Disease (GORD), is a disease of interest in gastroenterology that is caused by pathological complications of gastroesophageal reflux (GER). It may have several clinical presentations: disphagia, cough, rhinitis, burning in the jugular region, chest pain that mimics a heart attack, otitis. He definition of GERD is: “a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications” [1-3].
Source: Nutrition - Category: Nutrition Authors: Source Type: research
Conclusion: Overall, Amenity Health has created a very high quality product in their MedCline Reflux Relief System. It effectively prevents reflux and is, in my opinion, more comfortable than the more traditional wedges on the market. However, higher...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive GI Medicine Source Type: blogs
A 70-year-old white male with a longstanding history of allergic rhinitis and nasal polyposis, and relatively recent onset of chronic cough one year prior, presented to the hospital for one-week duration of neurologic complaints including chronic and worsening neck pain, bilateral upper extremity weakness, difficulty gripping objects, blurry vision, confusion, change in gait, and difficulty with initiation of urination. His medical history also included essential hypertension, dyslipidemia, gastroesophageal reflux, and shingles.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Challenging Clinical Cases Source Type: research
Authors: Gelardi M, Ciprandi G Abstract Introduction: Gastroesophageal reflux (GER) is a common disease usually limited to the oesophagus. Laryngopharyngeal reflux (LPR) is an inflammatory reaction of the mucosa of pharynx, larynx, and other associated upper respiratory organs, caused by a reflux of stomach contents outside the oesophagus. LPR is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated sometimes empirically and without a correct diagnosis. However, there is disagreement between specialists about its definition and management: gastroenterologi...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Anatomically, one of the primary defense mechanisms to prevent gastroesophageal reflux (GER) is an intact gastroesophageal junction (GEJ) that is composed of an overlapping lower esophageal sphincter and diaphragmatic crus (Figure  1). This barrier, if disrupted, can lead to increased GER and symptoms of gastroesophageal reflux disease (GERD) including heartburn, chest pain, regurgitation, and extraesophageal symptoms of cough or throat soreness. Prolonged or frequent GER can lead to complications including erosive esophagit is, Barrett’s esophagus, or stricture formation.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Here and Now: Clinical Practice Source Type: research
More News: Acid Reflux | Cardiology | Chemistry | Cough | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Heart | Speech-Language Pathology | Study