Counties in California sue manufacturers of opioid analgesics

This week, two counties in California sues five manufacturers of opioid analgesics, accusing them of carrying out a “campaign of deception” to boost sales of their products. According to a report in the Los Angeles Times: In sweeping language reminiscent of the legal attack against the tobacco industry, the lawsuit alleges the drug companies have reaped blockbuster profits by manipulating doctors into believing the benefits of narcotic painkillers outweighed the risks, despite “a wealth of scientific evidence to the contrary.” The effort “opened the floodgates” for such drugs and “the result has been catastrophic,” the lawsuit contends. The five defendants named in the suit are: Purdue Pharmaceuticals (OxyContin), Teva/Cephalon (Actiq and Fentora), Janssen (Duragesic and Ultram), Endo (Opana, Percoset, and Percodan), and Actavis (Kadian and various generics.) The 100-page filing is extremely detailed and the best document I know outlining the history of how use of opiate analgesics for chronic non-cancer pain — viewed as carrying a high risk of addiction and overdose not even 2 decades ago — became so common that in 2010 over 16,000 overdose deaths were linked to prescription opioids. According to the allegations, the defendant pharmaceutical companies engaged in a deceptive and fraudulent campaign to destigmatize opioids and minimize the associated risk of addiction. Tactics they used included: co-opting profes...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical lawsuit opiates opioid analgesics pain as fifth vital sign Source Type: news

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ConclusionsPamidronate is a safe and efficient method of CRMO therapy, particularly in cases refractory to NSAIDs treatment. Treatment with pamidronate provides both symptomatic relief as well as normalisation of bone morphology.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 16 June 2019Source: Joint Bone SpineAuthor(s): Pierre Letellier, Florian Bailly, Marina Assadourian, Antoine Potel, Violaine Foltz, Sophia Ascione, Laetitia Morardet, Myrianne Le Ralle, Bruno Fautrel, Arnaud Dupeyron, Nada Ibrahim-Nasser, Isabelle Griffoul-Espitalier, Bernard Duplan, Johann Beaudreuil, Laure Gossec
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Pfizer has agreed to buy Array Biopharma in a $10.64 billion cash deal.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
Nearly 6% of people in the study had a heart attack otrdeveloped angina (chest pain). The researchers found that all the people who developed heart trouble displayed a faster decline in their mental function at the same time.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Source: BMJ News - Category: General Medicine Source Type: research
CCR Grand Rounds Kimberly Stegmaier, M.D., Professor of Pediatrics at Harvard Medical School and the Ted Williams Chair at Dana-Farber Cancer Institute, has advanced the application of genomics to drug and protein target discovery for pediatric cancers. She is the Vice Chair for Pediatric Oncology Research, co-director of the Pediatric Hematologic Malignancy Program and an attending physician providing clinical care in Pediatric Oncology at the Dana-Farber Cancer Institute and Boston Children ’ s Hospital. Dr. Stegmaier is also an Institute Member of the Broad Institute of Harvard and MIT. She has served as a Council...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Abstract We hypothesize that, ancestrally, sex-specific immune modulation evolved to facilitate survival of the pregnant person in the presence of an invasive placenta and an immunologically challenging pregnancy - an idea we term the 'pregnancy compensation hypothesis' (PCH). Further, we propose that sex differences in immune function are mediated, at least in part, by the evolution of gene content and dosage on the sex chromosomes, and are regulated by reproductive hormones. Finally, we propose that changes in reproductive ecology in industrialized environments exacerbate these evolved sex differences, resulting...
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Tags: Trends Genet Source Type: research
Conclusions: WTP for fluoride varnish varied dramatically between individuals. In both countries, it was difficult to predict this variance, as factors which would likely impact upon on WTP had a limited effect and were sometimes counter-intuitive. WTP values for a parent and their child were not statistically significantly different.
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research
Conclusions: All treatments were found to effectively reduce bacterial counts (p 0.05) among treatments or between clinical variables (p> 0.05).
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research
During this first awards program the Office of Equity, Diversity and Inclusion (EDI) will honor these NIH employees and fellows who are community members and allies nominated for their exemplary work helping to create safer spaces for SGM at the NIH. These awardees lead by example and encourage others to demonstrate unconditional compassion, leadership, and understanding towards members of the SGM community: Dr. Vivian Ota Wang, National Cancer Institute; Dr. Christopher Wheldon, National Cancer Institute; Adam Cornish, National Institute on Aging; Dr. Karen Parker, Sexual&Gender Minority Research Office, Tricia Coffey...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
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