Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients

Publication date: Available online 31 March 2017 Source:Toxicology Reports Author(s): Belén Fernández, Isidro Ferrer, Fernando Gil, Sabine Hilfiker Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinsońs disease (PD) patients as compared to controls, which correlates with motor disability. Here, we have analyzed total iron levels in cells as well as mouse and human brain samples by atomic absorption spectroscopy (AAS). Our data indicate that iron load is more pronounced in cells with dopaminergic features. Moreover, region-specific differences in iron load reflecting those in the human brain were detected in rodent brains as well. Whilst altered iron load was not observed in other regions also affected in PD patients, we report a significant increase in iron load in the SN of Lewy body disease patients as compared to Alzheimeŕs disease (AD) patients or controls, which correlates with neurodegeneration in this brain area. Graphical abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research