Molecular pathology of anaplastic thyroid carcinomas: a retrospective study of 144 cases.

CONCLUSION: Our study confirms that ALK rearrangements in ATC are rare and that the mutational landscape of ATC is heterogeneous, involving many genes implicated in the follicular epithelial cell dedifferentiation process. This may explain the limited effectiveness of targeted therapeutic options tested so far. PMID: 28351340 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research