Tryptophan and Kynurenine Levels and Its Association With Sleep, Nonphysical Fatigue, and Depression in Chronic Hemodialysis Patients

Sleep and mood disorders are common in hemodialysis (HD) patients and the pathophysiology is still unclear. Tryptophan (TRP) and its metabolites may play a prominent role in neural pathways related to sleep, fatigue, and depression. Here, we sought to compare the levels of TRP and its metabolites between HD patients and healthy subjects and examine their association with sleep, fatigue, and depression in HD patients. The design was cross-sectional analysis.

Source: Journal of Renal Nutrition - March 30, 2017 Category: Urology & Nephrology Authors: Rakesh Malhotra, Vanja Persic, Weifang Zhang, Jill Brown, Xia Tao, Laura Rosales, Stephan Thijssen, Fredric O. Finkelstein, Mark L. Unruh, Alp Ikizler, Pranav S. Garimella, Joachim H. Ix, Jeroen Kooman, Nathan W. Levin, Garry J. Handelman, Peter Kotanko Tags: Original Research Source Type: research