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Duke ’s short lung transplant list saves CF patient

Treatment TermsCystic fibrosisPulmonary rehabilitationLung transplant CategoriesAdvanced treatments SEO Meta Description Cystic fibrosis patient Aimee Driscoll was given just hours to live. With no donor lungs available near her home in Maine, she was flown to Duke. Author MaryAnn Fletcher Overview Cystic fibrosis patient Aimee Driscoll was given just hours to live. With no donor lungs available near her home in Maine, she was flown to Duke. Hero Imageaimee_driscoll_blog.jpg Preview Image Content Blocks Section Header Image/Videoaimee_driscoll_blog2b.jpg Section Features Images/Media Text Content Header High-volume lung transplant center, shorter wait times ContentDuke ’slung transplant center, the highest-volume center in the Southeast, generally has shorter wait times for donor organs -- an average of about 14 days, compared with a national average of four months. The center also accepts difficult cases.Duke quickly dispatched a life flight team to transport Driscoll from Maine. “The carbon dioxide levels in her blood were more than twice what’s normal,” said Duke pulmonologistJohn Reynolds, MD.  “She was at risk for sudden respiratory failure.” The doctors in Maine had estimated she might have just hours to live. “They had my family say goodbye, in case I didn’t make it,” Driscoll said.To stabilize her for the flight, Duke cardiothoracic surgeonJohn C. Haney, MD, put Driscoll on a life-sustaining t...
Source: dukehealth.org: Duke Health News - Category: Consumer Health News Authors: Source Type: news

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AbstractObjectiveRecent literature reveals worse periodontal health condition in ankylosing spondylitis (AS). However, roles of AS-related parameters, periodontal condition, and their association appear unclear. This cross-sectional study aimed at investigating dental and periodontal health as well as potentially periodontal pathogenic bacteria in patients with AS compared to healthy control subjects (HC).MethodsDental examination comprised dental findings (DMF-T), periodontal probing depth (PPD), bleeding on probing, clinical attachment loss (CAL), papillary bleeding index, and microbiological analysis based on polymerase...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractPrimary graft failure can be a cause of early morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT), as it leads to a high risk of severe infections and bleeding. Splenomegaly is associated with primary graft failure in patients of myelofibrosis, but the association between splenomegaly and outcomes after HSCT in patients with myeloid malignancies has not been previously evaluated. The aim of this study was to investigate the effect of spleen volume on engraftment kinetics in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We enrolled 85 patients. The...
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractIn our retrospective study, 16 patients affected by advanced cutaneous T cell lymphoma (CTCL) underwent allogeneic hematopoietic stem cell transplantation (HSCT). Two patients (12.5%) were in complete remission (CR), nine (56.3%) in partial remission (PR), and five (31.2%) with active disease. The patients were transplanted from an HLA-identical (n = 7) from a mismatched (n = 1) or haploidentical (n = 1) sibling, from matched unrelated donor (n = 5), or from a single cord blood unit (n = 2). Conditioning regimen was standard myeloablative in 6 pa...
Source: Annals of Hematology - Category: Hematology Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
In this study, using multiparameter flow cytometry (FCM), we investigate the impact of minimal residual disease prior to transplantation (pre-MRD) on the transplant outcomes of AML patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) mutation. A total of 20 patients who received HLA-matched sibling donor transplantation (MSDT) and 63 patients who received unmanipulated haploidentical hematopoietic stem cell transplantation (haplo-HSCT) were enrolled. Patients were classified into four groups based on the status of pre-FCM: group 1 with positive pre-FCM before MSDT, group 2 with negative pre-...
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractMixed phenotype acute leukemia (MPAL) is an uncommon diagnosis, representing only about 2 –5% of acute leukemia cases. The blast cells of MPAL express multilineage immunophenotypic markers and may have a shared B/T/myeloid phenotype. Due to historical ambiguity in the diagnosis of MPAL, the genetics and clinical features of this disease remain poorly characterized. Based on the 2008 an d 2016 World Health Organization classifications, myeloid lineage is best determined by presence of myeloperoxidase, while B and T lymphoid lineages are demonstrated by CD19 and cytoplasmic CD3 expression. MPAL typically carrie...
Source: Annals of Hematology - Category: Hematology Source Type: research
One of my challenges in working with patients suffering from addictive illnesses is to help increase their motivation to stick with a long-term recovery plan. This is a significant challenge for many reasons, especially because the disease of addiction affects the brain's ability to value long term recovery. The one exception to this difficulty, in many cases, is when a female patient gets pregnant. I have witnessed women who struggled for years with an addictive illness discover they are pregnant and, when the pregnancy is wanted, are able to make incredible strides in their recovery. They are often able to maintain sobri...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
UR Medicine's Complex Care Center is Rochester’s first primary care practice dedicated to caring for adults with chronic childhood-onset conditions such as cystic fibrosis, sickle cell anemia, childhood cancers, autism, and intellectual and developmental disabilities.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Source Type: news
TRENTON, N.J. (AP) — The global pharmaceutical industry is pouring billions of dollars into developing treatments for rare diseases, which once drew little interest from major drugmakers but now point the way toward a new era of innovative therapies and big profits. The investments come as researchers harness recent scientific advances, including the mapping of the human genome, sophisticated and affordable genetic tests and laboratory robots that can screen thousands of compounds per hour in search of the most potent ones. "It's a very, very promising time," said Jimmy Lin, a National Institutes of Healt...
Source: Science - The Huffington Post - Category: Science Source Type: news
Funding Opportunity Number: RFA-AR-15-014 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCFDA Number: 93.846Eligible Applicants State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Public housing authorities/Indian housing authoritiesNative American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with th...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
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