Molecular characterization and antibiotic susceptibility of Haemophilus influenzae clinical isolates.

Molecular characterization and antibiotic susceptibility of Haemophilus influenzae clinical isolates. Infez Med. 2017 Mar 01;25(1):27-32 Authors: K L Ç H, Akyol S, Parkan ÕM, Dinç G, Sav H, Aydemir G Abstract Haemophilus influenzae can cause invasive and severe infections in both adults and children such as otitis media, sinusitis, pneumonia, meningitis and bacteremia. The emerging antibiotic resistance in recent years against ampicillin and several other antibiotics among strains of H. influenzae gives cause for serious concern. Here, we investigate ß-lactamase (BL) activity in clinical isolates of H. influenzae, profile their resistance to antibiotics, and characterize the clonal relationship of the isolates. Antibiotic susceptibilities of 92 clinical isolates of H. influenzae (March 2011-May 2012) were determined using the disk diffusion method according to the Clinical &Laboratory Standards Institute (CLSI), and BL activity was detected using the nitrocefin disk method. The Rep-PCR method was used to characterize clonality of the isolates. All strains were found to be susceptible to levofloxacin and cefotaxime. Four isolates out of 92 (4.3%) were found resistant to ampicillin, one isolate (1.1%) was resistant to amoxicillin/clavulanic acid, 21 isolates (22.8%) were resistant to trimethoprim-sulfamethoxazole (SXT), and three isolates (3.3%) showed BL activity. One strain was BL-negative but resistant to ampicillin. The th...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research

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Conclusions Overall, a majority of patients recovered well postoperatively with minimal complications and low rate of reoperation. Our research provides a foundation to develop a risk-stratified approach to determine the need for an ICU admission or early transfer to floor care.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Microsurgery Source Type: research
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Source: Patient Safety in Surgery - Category: Surgery Authors: Tags: Patient Saf Surg Source Type: research
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In this study, the effects of PHD2 in colon cancer were evaluated, and the underlying molecular mechanisms were investigated. The results showed that overexpressing PHD2 exerted proliferative and migratory inhibition in colon cancer cells. The expression of cell cycle and epithelial-mesenchymal transition (EMT)-associated proteins were changed: CyclinD1, CDK4, N-cadherin, and Vimentin were down-regulated, while E-cadherin was up-regulated in PHD2-overexpressing colon cancer cells. Moreover, in colon cancer xenograft mice, PHD2 overexpression suppressed tumor growth accompanied by decreased Ki67 expression. Importantly, we ...
Source: Life Sciences - Category: Biology Source Type: research
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Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
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Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Flu Source Type: news
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Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conditions:   Community Acquired Pneumonia;   Complicated Skin and Soft Tissue Infection Intervention:   Drug: Zinforo (ceftaroline fosamil) Sponsor:   Pfizer Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Helicobacter Pylori Interventions:   Drug: Vonoprazan;   Drug: Amoxicillin;   Drug: Clarithromycin;   Drug: Bismuth Potassium citrate;   Drug: Esomeprazole Sponsor:   Takeda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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