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Female menstrual cycle in a dish

(Northwestern University) What if women could have a miniature, personalized reproductive system made with their own tissues that could predict how they would respond to certain medications? Northwestern has developed the first phase of this technology, made with human tissue, which could eventually change the future of research and treatment of diseases in women's reproductive organs. It will allow physicians to test drugs for safety and effectiveness and better understand such diseases as endometriosis, fibroids, cancer and infertility.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Abstract Endometriosis is a common and challenging condition of reproductive-aged women that carries a high individual and societal cost. The many molecular dissimilarities between endometriosis lesions and eutopic endometrium create difficulties in the development of new drug therapies and treatments. Surgery remains the gold standard for definitive diagnosis, but it must be weighed against the risks of surgical morbidity and potential decreases in ovarian reserve, especially in the case of endometriomas. Safe and effective surgical techniques are discussed within this article for various presentations of endomet...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
(Abstracted from BJOG 2018;125(1):64–72) The mainstay for the diagnosis and treatment of endometriosis is surgery. After the initial surgery, women often undergo multiple operations in an attempt to alleviate persistent symptoms of pain and infertility.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: Gynecology: Office Gynecology Source Type: research
We acknowledge the ongoing concerns of women with endometriosis, a chronic gynaecological condition affecting about 176 million women worldwide, regarding information about their increased ovarian cancer risk. Endometriosis is an inflammatory disease process characterised by lesions of endometrial-like tissue outside the uterus —commonly on the pelvic peritoneum and ovaries—that is associated with debilitating pelvic pain and infertility.1 Although benign, endometriosis has cancer-like features,2 a mutation profile similar to that of ovarian cancer,3 and an increased ovarian cancer risk.
Source: LANCET - Category: General Medicine Authors: Tags: Correspondence Source Type: research
AbstractIntroductionWe sought to characterize changes in healthcare spending associated with the onset of 22 endometriosis-related comorbidities.MethodsWomen aged 18 –49 years with endometriosis (N = 180,278) were extracted from 2006–2015 de-identified Clinformatics® DataMart claims data. For 22 comorbidities, comorbidity patients were identified on the basis of having a first comorbidity diagnosis after their initial endometriosis diagnosis. Controls were identified on the basis of having no comorbidity diagnosis and were matched 1:1 to comorbidity patients on demographics and baseline spend...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Conclusion This case illustrates a presentation of endometriosis in a postmenopausal woman mimicking advanced mullerian malignancy. The patient's estrogenic state from obesity in combination with the agonist action of the tamoxifen likely contributed to her rare presentation. While findings such as a thickened endometrial stripe are typical of tamoxifen use, such widespread proliferation of endometriosis resulting in a pelvic mass, genito-urinary obstruction, and plaque-like pelvic spread are not. Précis Endometriosis is a benign estrogen dependent condition rarely problematic in a postmenopausal patient. Tamoxifen ...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Apigenin is a plant‐derived flavonoid having antiproliferative, anti‐inflammatory, and anti‐angiogenic properties in chronic and metabolic diseases, and cancers. However, the functional role of apigenin remains to be identified in human endometriosis that is a benign inflammatory disease causing infertility, dysmenorrhea, dyspareunia, and chronic abdominal or pelvic pain. In the present study, we determined the effects of apigenin on two well‐established human endometriosis cell lines (VK2/E6E7 and End1/E6E7). Apigenin reduced proliferation and induced cell cycle arrest and apoptosis in the both endometriosis cell ...
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Semin Reprod Med 2017; 35: 263-270 DOI: 10.1055/s-0037-1603582Endometriosis is a condition defined by the presence of endometrial glands and stroma in ectopic locations. While the most commonly seen symptoms of the disease are pelvic pain, dysmenorrhea, and infertility, endometriosis has also systemic effects in multiple organ systems. Here, we review literature describing closely associated comorbidities including cardiovascular disease, cancers, autoimmune disease, psychiatric conditions, and metabolism/body weight. We examine the pathophysiology and hypothesized mechanism by which endometriosis may lead to these systemi...
Source: Seminars in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Review Article Source Type: research
Endocrine is an important and tightly regulated system for maintaining body homeostasis. Endocrine glands produce hormones, which are released into blood stream to guide the target cells responding to all sorts of stimulations. For maintaining body homeostasis, the secretion and activity of a particular hormone needs to be adjusted in responding to environmental challenges such as changes in nutritional status or chronic stress. Hypoxia, a status caused by reduced oxygen availability or imbalance of oxygen consumption/supply in an organ or within a cell, is a stress that affects many physiological and pathological processe...
Source: Journal of Endocrinology - Category: Endocrinology Authors: Tags: Review Source Type: research
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Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract The hormone estrogen is involved in both female and male reproduction, as well as numerous other biological systems including the neuroendocrine, vascular, skeletal, and immune systems. Therefore, it is also implicated in many different diseases and conditions such as infertility, obesity, osteoporosis, endometriosis, and a variety of cancers. Estrogen works through its two distinct nuclear receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). Various transcriptional regulation mechanisms have been identified as the mode of action for estrogen, mainly the classical mechanis...
Source: Current Topics in Developmental Biology - Category: Biology Authors: Tags: Curr Top Dev Biol Source Type: research
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