Short-term association between road traffic noise and healthcare demand generated by Parkinson's disease in Madrid, Spain.

CONCLUSION: The above results indicate that road traffic noise is a risk factor for PD exacerbation. Measures to reduce noise-exposure levels could result in a lower PD-related healthcare demand. PMID: 28343738 [PubMed - as supplied by publisher]
Source: Gaceta Sanitaria - Category: Global & Universal Tags: Gac Sanit Source Type: research

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Conclusions: This review summarizes a model of microbiota-gut-brain-axis regulation of neuroinflammation in PD including several new mechanisms. We conclude with the need for clinical trials in PD patients to test this model for beneficial effects of Mediterranean based high fiber diets.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
We aimed to evaluate microscale changes in the bilateral red nucleus and substantia nigra of patients with Parkinson's disease (PD) using diffusion kurtosis imaging (DKI). Twenty-six patients with PD [mean age, 62.5 ± 8.7 years; Hoehn-Yahr stage, 0–4.0; Unified Parkinson's Disease Rating Scale (UPDRS) scores, 8–43] and 15 healthy controls (mean age, 59.5 ± 9.4 years) underwent DKI of the substantia nigra and red nucleus. Imaging was performed using a General Electric (GE) Signa 3.0-T MRI system. Patients with PD were divided into two groups consisting of 12 patients with UPDRS scores ≥ 30 and 1...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Many people suffer from an inability to focus on tasks that require a great deal of attention. Drugs such as Ritalin are available to help mitigate symptoms of attention-deficit/hyperactivity disorder (ADHD) and related conditions, but these medicati...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Psychiatry Source Type: blogs
Visual hallucinations (VHs) are common in patients with Parkinson disease (PD), especially those with dementia, whereas auditory hallucinations are quite rare. Recent studies have revealed the involvement of several regions along the visual information-pro...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson's disease (PD). Previously, we reported the structure of alpha-synuclein fibrils (residues 1-121), composed of two protofibrils that are connected via a densely-packed interface formed by residues 50-57 (Guerrero-Ferreira, eLife 218;7:e36402). We here report two new polymorphic atomic structures of alpha-synuclein fibrils termed polymorphs 2a and 2b, at 3.0 Å and 3.4 Å resolution, respectively. These polymorphs show a radically different structure compared to previously reported polymorphs. ...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Structural Biology and Molecular Biophysics Source Type: research
This study aimed to investigate the safety and efficacy of MRgFUS for PD by systematically reviewing related literature. PubMed and EMBASE were searched to identify related studies. Inclusion criteria were (1) reported the efficacy or sa fety of MRgFUS for PD and (2) published in English. Exclusion criteria were (1) nonhuman study, (2) review or meta-analysis or other literature types without original data, and (3) conference abstract without full text. Data on study characteristics, treatment parameters, efficacy, and adverse event s were collected. Descriptive synthesis of data was performed. Eleven studies containing 80...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Visual hallucinations (VH) are commonly found in the course of synucleinopathies like Parkinson's disease and dementia with Lewy bodies. The incidence of VH in these conditions is so high that the absence of VH in the course of the disease should raise questions about the diagnosis. VH may take the form of early and simple phenomena or appear with late and complex presentations that include hallucinatory production and delusions. VH are an unmet treatment need. The review analyzes the past and recent hypotheses that are related to the underlying mechanisms of VH and then discusses their pharmacological modulation. Recent m...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractParkinson ’s disease (PD) is a neurodegenerative pathology resulting from the degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Neurotrophic factors (NTFs) and their receptors are key regulators of the survival, differentiation, and development of neurons. However, the role of these fa ctors in the pathogenesis of PD is still unclear. Here, we analyzed the expression of NTFs and their receptors in human induced pluripotent stem cells (iPSCs) derived from the fibroblasts of patients with PD and healthy donors (HDs). Four PD-derived iPSC lines with different mutations and three cell lines ...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
In patients with acute-onset paraparesis inferior, the concurrent presence of new onset cortical signs (abulia or mutism), and more rarely extrapyramidal signs, should alert clinicians to consider acute anterior bihemispheric ischemia. Prompt recognition of this rare form of acute cerebral stroke can enable timely delivering of acute thrombolytic or endovascular treatment.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: All Imaging, All Clinical Neurology, Clinical neurology examination, Parkinson's disease/Parkinsonism, All Cerebrovascular disease/Stroke Case Source Type: research
During a hospitalization for sepsis in the setting of a urinary tract infection, a 69-year-old man with idiopathic Parkinson disease (PD) developed severe, sudden-onset left-sided neck pain an hour after receiving quetiapine to treat hospital delirium, raising concern for acute dystonic reaction. On review of the patient's history, he had received single doses of haloperidol and quetiapine 1 week and 3 days prior, respectively, without documented dystonic reaction. He had a history of dystonia in his right foot, which was well controlled with botulinum toxin injections. On examination, his head was rotated toward the right...
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Clinical neurology examination, All Movement Disorders, Dystonia, Parkinson's disease/Parkinsonism, Botulinum toxin Case Source Type: research
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