Genetic Heterogeneity in Depressive Symptoms Following the Death of a Spouse: Polygenic Score Analysis of the U.S. Health and Retirement Study.

CONCLUSIONS: The effects were small, and the clinical relevance is uncertain, although polygenic score analyses may provide clues to behavioral pathways that can serve as therapeutic targets. Future studies of gene-environment interplay in depression may benefit from focus on genetics discovered for putative protective factors.
PMID: 28335623 [PubMed - as supplied by publisher]

Source: The American Journal of Psychiatry - March 24, 2017 Category: Psychiatry Authors: Domingue BW, Liu H, Okbay A, Belsky DW Tags: Am J Psychiatry Source Type: research