Modeling Syndromic Congenital Heart Defects in Zebrafish.

Modeling Syndromic Congenital Heart Defects in Zebrafish. Curr Top Dev Biol. 2017;124:1-40 Authors: Grant MG, Patterson VL, Grimes DT, Burdine RD Abstract Cardiac development is a dynamic process regulated by spatial and temporal cues that are integrated to effect molecular, cellular, and tissue-level events that form the adult heart. Disruption of these highly orchestrated events can be devastating for cardiac form and function. Aberrations in heart development result in congenital heart defects (CHDs), which affect 1 in 100 infants in the United States each year. Zebrafish have proven informative as a model organism to understand both heart development and the mechanisms associated with CHDs due to the similarities in heart morphogenesis among vertebrates, as well as their genetic tractability and amenability to live imaging. In this review, we discuss the mechanisms of zebrafish heart development and the utility of zebrafish for understanding syndromic CHDs, those cardiac abnormalities that occur in the context of multisystem disorders. We conclude with avenues of zebrafish research that will potentially inform future therapeutic approaches for the treatment of CHDs. PMID: 28335857 [PubMed - in process]
Source: Current Topics in Developmental Biology - Category: Biology Authors: Tags: Curr Top Dev Biol Source Type: research

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Publication date: Available online 15 October 2018Source: Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical SciencesAuthor(s): James W.E. LoweAbstractDNA sequencing has been characterised by scholars and life scientists as an example of ‘big’, ‘fast’ and ‘automated’ science in biology. This paper argues, however, that these characterisations are a product of a particular interpretation of what sequencing is, what I call ‘thin sequencing’. The ‘thin sequencing’ perspective focuses on the determinatio...
CONCLUSION: Percutaneous transvenous retrieval is a safe, minimally invasive and relatively simple procedure for the patients with fractured catheter and should be recommended as the first choice. PMID: 30320599 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
Publication date: Available online 16 October 2018Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Arunaksharan Narayanankutty, Anu Anil, Soorya Parathodi Illam, Sruthi Panniyan Kandiyil, Achuthan C. RaghavamenonAbstractThermal oxidation products of edible oils including aldehydes, peroxides and polymerized triglycerides formed during the cooking process is increasingly debated as contributory to chronic degenerative diseases. Depending on the oil used for cooking, the source of fatty acids and its oxidation products may vary and would have a differential influence on the physiological process. Coco...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
In this study, control and 5-LO-expressing HEK293 cells were stimulated in the presence of 20:4 n-3. Metabolites were characterized by LC-MS/MS and their anti-inflammatory properties assessed using AA-induced autocrine neutrophil stimulation and leukotriene B4-mediated chemotaxis. 8-hydroxy-9,11,14,17-eicosatetraenoic acid (Δ17-8-HETE) and 8,15-dihydroxy-9,11,13,17-eicosatetraenoic acid (Δ17-8,15-diHETE) were identified as novel metabolites. Δ17-8,15-diHETE production was inhibited by the leukotriene A4 hydrolase inhibitor SC 57461A. Autocrine neutrophil leukotriene stimulation and neutrophil chemotaxis, ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
In this study, whether autocrine IL‑10 regulates Op18/stathmin signaling in NCI‑H1299 cells was examined by neutralizing IL‑10 using a targeted antibody. In vitro neutralization of IL‑10 by anti‑IL‑10 antibody impaired the capacities of the NCI‑H1299 cells to proliferate, form colonies and migrate. Furthermore, the expression levels of caspase‑3 and ‑8, and sensitivity to Taxol were increased. Neutralizing IL‑10 downregulated Op18/stathmin expression and its phosphorylation at Ser25 and Ser63 sites, and suppressed the activities of upstream kinases, extracellular signal‑regulated kinase (ERK...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Zhao Y, Onda K, Sugiyama K, Yuan B, Tanaka S, Takagi N, Hirano T Abstract In the present study, the antitumor effects of arsenic disulfide (As2S2) on the proliferative, survival and migratory ability of human breast cancer MCF‑7 and MDA‑MB‑231 cells were investigated, and its potential underlying molecular mechanisms with an emphasis on cell cycle arrest, apoptosis induction, autophagy induction and reactive oxygen species (ROS) generation were determined. The results indicated that As2S2 significantly inhibited the viability, survival and migration of breast cancer cells in a dose‑dependent m...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Zhuang L, Lai J, Chen K, Ding T, Yuan Y, Ma Y, Kang H, Lin Z, Fan N, Ma J, Zeng Q, Xu X, Wang Q, Chen B Abstract The aim of the present study was to prospectively evaluate the recurrence and survival outcome of primary central nervous system lymphoma (PCNSL) with intraocular involvement. For this purpose, a prospective cohort of 103 pathologically confirmed patients with PCNSL was enrolled in this study. Ophthalmologic examinations were performed both at diagnosis and during follow‑up. The patients with PCNSL with suspected intraocular involvement underwent vitrectomy for confirmation. Patients who prese...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Inhibitory effects of Schisandrin B on human prostate cancer cells. Oncol Rep. 2018 Oct 15;: Authors: Nasser MI, Han T, Adlat S, Tian Y, Jiang N Abstract Prostate cancer is a serious affliction worldwide. Although much progress has been made in the study of prostate cancer prevention and treatment, less attention has been paid to the molecular mechanism of the disease. The molecular arrangement by which Schisandrin B (Sch B) induces human prostate cancer cytotoxicity was comprehensively examined in the present study. As indicated by the results of flow cytometric and western blot analysi...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In conclusion, the present study demonstrated the feasibility of using the radiocobalt labeled anti‑EGFR affibody conjugate ZEGFR:2377 as an imaging agent for in vivo visualization of low EGFR‑expressing tumors, like PCa, and for monitoring of receptor occupancy during cetuximab therapy as well as the importance of optimal dosing in order to achieve higher sensitivity molecular imaging. PMID: 30320363 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Targeting LRH‑1 in hepatoblastoma cell lines causes decreased proliferation. Oncol Rep. 2018 Oct 15;: Authors: Jin J, Jin J, Woodfield SE, Patel RH, Jin NG, Shi Y, Liu B, Sun W, Chen X, Yu Y, Vasudevan SA Abstract Hepatoblastoma is the most common malignant liver tumor in children. Since it is often unresectable and exhibits drug resistance, the treatment of advanced hepatoblastoma is challenging. The orphan nuclear receptor liver receptor homolog‑1 (LRH‑1) serves prominent roles in malignancy; however, to the best of our knowledge, the role of LRH‑1 in hepatoblastoma remains unknown. In the pr...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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