Modeling Syndromic Congenital Heart Defects in Zebrafish.
Modeling Syndromic Congenital Heart Defects in Zebrafish. Curr Top Dev Biol. 2017;124:1-40 Authors: Grant MG, Patterson VL, Grimes DT, Burdine RD Abstract Cardiac development is a dynamic process regulated by spatial and temporal cues that are integrated to effect molecular, cellular, and tissue-level events that form the adult heart. Disruption of these highly orchestrated events can be devastating for cardiac form and function. Aberrations in heart development result in congenital heart defects (CHDs), which affect 1 in 100 infants in the United States each year. Zebrafish have proven informative as a model organism to understand both heart development and the mechanisms associated with CHDs due to the similarities in heart morphogenesis among vertebrates, as well as their genetic tractability and amenability to live imaging. In this review, we discuss the mechanisms of zebrafish heart development and the utility of zebrafish for understanding syndromic CHDs, those cardiac abnormalities that occur in the context of multisystem disorders. We conclude with avenues of zebrafish research that will potentially inform future therapeutic approaches for the treatment of CHDs. PMID: 28335857 [PubMed - in process]
Wulf R össler, Jules Angst, Vladeta Ajdacic-Gross, Helene Haker, Sofian Berrouiguet, Mariam Ujeyl, Nicholas Glozier, Michael P. Hengartner
J ürgen Fuchshuber, Michaela Hiebler-Ragger, Adelheid Kresse, Hans-Peter Kapfhammer, Human F. Unterrainer
BREAST cancer symptoms and signs develop when a few cells in this area start to divide uncontrollably. The most common cancer in women, there are also rare cases of the cancer developing in men. Watch out for these warning signs of breast cancer.
Many famous studies of human behavior cannot be reproduced. Even so, they revealed aspects of our inner lives that feel true.
PMID: 30005795 [PubMed - in process]