Major EPSRC Programme Grant to support new Oxford Centre for Drug Delivery Devices

(Engineering and Physical Sciences Research Council) Cancer therapy drugs tend to achieve limited accumulation and poor penetration in tumors, reducing their effectiveness. For many years, the only methods used to improve drug uptake by tumors have been pharmacological, and these have had limited success. Recent research at Oxford University has shown that physical mechanisms triggered by ultrasound, magnetic fields or shock waves can dramatically improve the delivery and penetration of existing and experimental drugs into tumors.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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ConclusionsIn conclusion, we demonstrate that Oncologist-led rapid access clinics are successful concepts to assess patients with unexplained lymphadenopathy. Our data suggest that a routine use of FNA should be reconsidered in this setting.
Source: BMC Hematology - Category: Hematology Source Type: research
CONCLUSIONS: Targeted MRI/TRUS fusion-guided focal HIFU allows local tumor ablation, but is not free from limitations. The procedure has good functional outcomes and a quick recovery. Multicenter trials with more patients are required to determine the procedure´s role in the prostate cancer therapy algorithm. PMID: 30093211 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract  Theranostics is a term used to describe the combination of diagnostic and therapeutic functions in a single agent. Ultrasound, for example, is a good tool for theranostics due to its multi-potency as both a diagnostic tool using sonography, and as a therapeutic, i.e., by high intensity focused ultrasound (HIFU). Likewise, microbubbles and nanobubbles are not only used as contrast imaging agents, but also as enhancers of drug delivery. Recently, the combination of these bubbles with low intensity ultrasound has been utilized as an effective drug delivery system. We have implemented a similar technique b...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Conclusion: The co-delivery of Gem and miR-21i using Au DENPs can be significantly promoted by UTMD technology, hence providing a promising strategy for effective pancreatic cancer treatments.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - Category: Nanotechnology Authors: Source Type: research
Authors: Salkho NM, Paul V, Kawak P, Vitor RF, Martins AM, Al Sayah M, Husseini GA Abstract A new modality of drug targeting to tumors has been proposed. The ligand-mediated approach, that already increases the therapeutic index of the drug, can still be optimized by the encapsulation of the drug into sonosensitive nanoparticles. In this work, an endogenous ligand, estrone, was used to synthesize doxorubicin-encapsulating liposomes for estrogen receptor (ER)-positive breast cancer therapy with cyanuric chloride (2,4,6 trichloro-1,3,5 triazine) being used as a linking molecule to attach 3-OH group of estrone to the ...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
AbstractPurpose of ReviewThe landscape of lung cancer therapy has completely shifted in the last decade. From the surge of targeted therapy to the resurrection of immunotherapy, the need for adequate lung tissue specimen is critical to evaluate tumor specimens for predictive biomarkers for both types of therapies, hence, the importance of obtaining several samples via endoscopic bronchial ultrasound performed by pulmonologists or thoracic surgeons. Moreover, these novel therapies have also been associated with respiratory side effects which will require prompt evaluation and aggressive management by pulmonologists, oncolog...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
Abstract Mesoporous silica nanoparticles (MSNs) have been demonstrated to be one of the most promising drug delivery systems (DDSs) to transport a variety of drug/biomolecules. Functionalization of MSN surfaces with responsive polymer brushes endows them with intelligent and controllable drug delivery properties, i.e., the encapsulated drugs/biomolecules will only be released upon certain stimuli including pH, temperature variation, light irradiation, enzyme, ultrasound, or redox potential, thus maximizing their therapeutic efficiency and minimizing side effects. These polymer brushes can also increase the stabili...
Source: Chemphyschem - Category: Chemistry Authors: Tags: Chemphyschem Source Type: research
Journal of Cardiovascular Disease Research,2018,9,1,1-4.DOI:10.5530/jcdr.2018.1.1Published:March 2018Type:Review ArticleBreast Cancer and the Heart: Burden on the ChestAjit Singh,Hashir Kareem,Tom Devasia,Kanav Khera,Sheetal Chauhan,Yeswanth Rao K,andGanesh PAjit Singh*1, Hashir Kareem1, Tom Devasia1, Kanav Khera2, Sheetal Chauhan3, Yeswanth Rao K3, Ganesh P11Department of Cardiology, Kasturba Medical College and Hospital, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.2Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA...
Source: Journal of Cardiovascular Disease Research - Category: Cardiology Authors: Source Type: research
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