Major EPSRC Programme Grant to support new Oxford Centre for Drug Delivery Devices

(Engineering and Physical Sciences Research Council) Cancer therapy drugs tend to achieve limited accumulation and poor penetration in tumors, reducing their effectiveness. For many years, the only methods used to improve drug uptake by tumors have been pharmacological, and these have had limited success. Recent research at Oxford University has shown that physical mechanisms triggered by ultrasound, magnetic fields or shock waves can dramatically improve the delivery and penetration of existing and experimental drugs into tumors.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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In conclusion, drug-conjugated micellar nanoparticles are more desirable for SDT because of accelerated ROS production and drug protection from ROS. Furthermore, a combination of NC-6300 and TP-HIFU is useful for minimally invasive cancer therapy with cooperative effects of HIFU-derived features, antitumor activity of EPI, and increased ROS generation to cause damage to cancer cells.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Magnetic resonance-guided transurethral ultrasound ablation is an ablative technology for prostate cancer that destroys nearly the whole gland but leaves urinary function intact.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
In conclusion, e-As4S4 holds great potential for an alternative therapeutics in the treatment of breast cancer, due to its unique function of correcting the aggressive microenvironment. Introduction Metastasis is the leading cause of breast cancer mortality, which has been one major challenge in clinical treatment (1). In particular, triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptors (ER), progesterone receptors (PR) and HER2 receptors, which is one of the most aggressive types of breast cancers, marked by high rates of relapse, visceral metastases and early death (2, 3). The...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Mark E. Gray1,2*, James Meehan2,3, Paul Sullivan4, Jamie R. K. Marland4, Stephen N. Greenhalgh1, Rachael Gregson1, Richard Eddie Clutton1, Carol Ward2, Chris Cousens5, David J. Griffiths5, Alan Murray4 and David Argyle1 1The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom 2Cancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 3School of Engineering and Physical Sciences, Institute of Sensors, Signals and Systems, Heriot-Watt Univer...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Personalized Dendritic Cell Vaccines—Recent Breakthroughs and Encouraging Clinical Results Beatris Mastelic-Gavillet, Klara Balint, Caroline Boudousquie, Philippe O. Gannon and Lana E. Kandalaft* Department of Oncology, Center for Experimental Therapeutics, Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland With the advent of combined immunotherapies, personalized dendritic cell (DC)-based vaccination could integrate the current standard of care for the treatment of a large variety of tumors. Due to their proficiency at antigen presentation, DC are key coordinators of the innate...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Cancer has become one of the most deadly non-communicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy and low side effects. The most common example of such modalities is the use chemotherapeutic drugs to destroy cancerous cells and deter their uncontrolled proliferation. Parallel to the destruction of cancerous tissue; chemotherapy destroys normal, healthy tissues, as it lacks the specificity to annihilate cancerous cells preferentially resulting in adverse side effects that include nausea, hair fall, and cardiac infarction. T...
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research
Getting drugs to treat maladies in the brain is hampered by the blood-brain barrier, a protective shield that makes sure only the right chemicals pass through. Ultrasound has become a promising way of opening up pathways in the blood-brain barrier to...
Source: Medgadget - Category: Medical Devices Authors: Tags: Medicine Neurology Radiology Source Type: blogs
In this study, pegylated (stealth) liposomes conjugated to human serum albumin (HSA) were investigated for the delivery of a model drug (calcein) to breast cancer cells. The fluorescent results showed that calcein uptake by the two breast cancer cell lines (MDA-MB-231 and MCF-7) was significantly higher with the HSA-PEG liposomes compared to the non-targeted control liposomes. Furthermore, the exposure to low-frequency ultrasound (LFUS) resulted in a statistically significant uptake of calcein compared to the uptake without ultrasound. The described drug delivery (DD) system, which involves combining the targeted liposomal...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Publication date: 1 August 2019Source: Chemical Engineering Journal, Volume 369Author(s): Jian Chen, Xiaobo Wang, Yibiao Liu, Huili Liu, Fengli Gao, Chong Lan, Baocheng Yang, Shouren Zhang, Yongju GaoAbstractWe develop pH-responsive GOD@CaCO3-Fe3O4 particles as catalytic nanomedicine for chemodynamic therapy through ultrasound-assisted Fenton reaction. By loading glucose oxidase (GOD) in the interior of the particles, GOD can be well protected and effectively delivered to catalyze glucose in cancer cells. A considerable amount of H2O2 is then generated for Fenton reaction by reacting with Fe3O4 nanoparticles. The introduct...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b21968
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
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