Longitudinal evaluation of perfusion changes in acute and chronic renal allograft rejection using arterial spin labeling in translational mouse models

PurposeTo examine the longitudinal changes of renal perfusion due to acute and chronic renal allograft rejection by using arterial spin labeling (ASL) MRI in translational mouse models of isogenic and allogenic kidney transplantation (ktx). Materials and MethodsAcute rejection was induced by allogenic ktx of C57BL/6 (B6)‐kidney grafts to BALB/c‐recipients with prolonged cold ischemia (CIT) of 60 minutes (n = 13). To induce chronic rejection BALB/c‐kidneys were transplanted into B6‐recipients with short CIT of 30 minutes (n = 22). Isogenic grafts without rejection (n = 14 with prolonged, n = 9 with short CIT) and normal kidneys (n = 22) were used for comparison. Perfusion was measured on a 7T small‐animal magnetic resonance imaging (MRI) scanner using flow‐sensitive alternating inversion recovery (FAIR) ASL‐sequences at day 1 and 6 (acute) or at week 3 and 6 (chronic) after surgery. Histological analyses of grafts included inflammation, vascular changes, and fibrosis. ResultsIn the acute ktx model, ASL showed perfusion impairment in isogenic and allogenic kidney grafts. Perfusion of allografts further decreased until day 6 and remained stable in isografts without rejection (allogenic ktx 62 ± 21 vs. isogenic ktx 181 ± 39 ml/min/100g, P
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research

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ConclusionsWe identified diabetes and hyperlipidemia as potential risk factors for development of high BK viremia and/or BKVN. IVIG was seen to be effective in reducing viral titers. The period 3–9 months post-transplantation was identified as important for development of BKVN from high BK viremia.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Authors: Kim MS, Kim GH, Lee CH, Park JS, Lee JY, Tae K Abstract Objectives: The aim of this study was to evaluate the effectiveness of subtotal parathyroidectomy for patients with renal hyperparathyroidism. Methods: We studied 25 patients with renal hyperparathyroidism who underwent subtotal parathyroidectomy from October 2002 to October 2017. We analyzed serum intact parathyroid hormone (iPTH), calcium, and inorganic phosphorus levels before and at multiple time points following surgery, and evaluated the surgical outcomes and complications. Results: Of the 25 patients, 13 (52%) were male and 12 (48%) wer...
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
Publication date: Available online 21 February 2020Source: Urology Case ReportsAuthor(s): Tomotaka Yamazaki, Hiroyuki Shirai, Jun Yashima, Tamotsu TojimbaraAbstractThe patient was a 41-year-old male who had been maintained on extended-hours hemodialysis for 297 months. Despite of long-term hemodialysis vintage, he had no vascular calcification and ectopic calcification. His kidney graft did not experience rejection or other complications 18 months after the cadaveric kidney transplant. Previous reports indicated that graft survival of extended-hours hemodialysis patients did not differ from conventional hemodialysis. Howev...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
This study aims to further characterise the LALV and proposes a novel classification for its relation to other veins.Dissection of the LRV system, including the left suprarenal vein (LSV), left gonadal vein (LGV) and LALV, was performed in 38 cadavers. Their drainage points into the LRV were recorded, and measurements taken of the distances from these points to the junction of the LRV and inferior vena cava (IVC).The position of the LRV in relation to the aorta was anterior in 35 cases (92%), entirely posterior in 1 case (3%), and circumaortic in 2 cases (5%). Duplication of the LSV and LGV occurred in 6 (16%) and 10 (27%)...
Source: The Surgeon - Category: Surgery Source Type: research
This study analyzed a large number of kidney transplant (KT) recipients (n = 170,684) from the US, reported the long -term outcomes of KT in 11,691 patients with pre-transplant malignancy (pre-TM), and concluded that pre-TM was associated with increased risk of post-transplant (post-TM) malignancy, increased 5- and 10-year rates of graft loss, and decreased patient survival.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
Authors: Ponticelli C, Arnaboldi L, Moroni G, Corsini A Abstract Introduction: Lipid disorders are frequent after kidney transplantation (KT) and KT recipients are considered at high- or very-high cardiovascular risk. Among many concurring factors, a major role is played by immunosuppressants.Areas covered: General measures to manage lipid disorders first include physical activity and diet counseling. Modulating the doses of immunosuppressants also improves dyslipidemia. When lipid-lowering drugs are necessary to control elevated plasma cholesterol and/or triglycerides, statins are the cornerstone for managing hype...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
ConclusionsWe found a significantly increased five-year survival rate for heart-kidney transplant recipients compared to isolated heart transplant recipients with renal impairment. Lack of improvement in five-year post-operative outcomes for heart-kidney recipients in the setting of higher risk pre-transplant clinical characteristics suggests decreased selectivity regarding heart-kidney recipients. Continued scrutiny and evaluation of post-operative outcomes are required to ensure just and appropriate utilization of organs.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Patients with end-stage renal disease may use peritoneal dialysis (PD) for convenience and flexibility. However, PD catheters may have associated adverse outcomes, including discomfort, inadequate dialysis, malfunction, and infection. Some of them may transition to Hemodialysis or possibly get a kidney transplant during their lifetime. Our study sought to determine the outcomes of patients who had PD catheters placed by Interventional radiologists over a 2-year period.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
Percutaneous core needle biopsy of the transplant kidney is an essential diagnostic tool for the evaluation of renal allograft dysfunction. However, arteriovenous fistulas (AVFs) are a recognized complication with a reported incidence of 5-10%. Endovascular embolization is the current first line treatment with technical and clinical success rates of 71-100% and 57-100%, respectively. This procedure, however, may be limited by contrast-induced nephropathy. The following study evaluates the efficacy and safety of percutaneous ultrasound (US)-guided coil embolization of postbiopsy renal transplant AVFs.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Traditional Poster Source Type: research
Survival after kidney transplantation during childhood and adolescence has improved substantially in the past four decades, according to findings from the Australian and New Zealand Dialysis and Transplantation (ANZDATA) Registry.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Transplantation News Source Type: news
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