Survey on Clinical Practice of Primary Prophylaxis in Portal Hypertension in Children
In conclusion, despite the absence of scientific recommendations there is a tacit consensus concerning the need to screen children with clinical signs of portal hypertension, and to provide primary prophylaxis in cases of endoscopic patterns of high-risk varices.
Conclusions: Some normotensive IgA nephropathy patients with mild proteinuria had impaired renal function at diagnosis. Ischemic sclerosis and fibrous crescent were the main pathological features in these patients. Patients in the crescent group had a worse outcome than patients in the ischemic sclerosis group. PMID: 31517550 [PubMed - in process]
Publication date: Available online 13 September 2019Source: Saudi Journal of Biological SciencesAuthor(s): Lixia Zhang, Gang Wang, Jianhui Gan, Zhongci Dou, Liying BaiAbstractObjectiveTo elaborate the analgesic efficiency of midazolam-induced anesthesia in different doses on the patients following the thoracoscopic resection of lung cancer.MethodsNinety patients undergoing thoracoscopic resection of lung cancer between August 2017 and July 2018 were randomized in the observation group (n=45) and the control group (n=45). Patients in observation group underwent the anesthesia induced by 0.1 mg/kg midazolam, while for the co...
Publication date: Available online 13 September 2019Source: Life SciencesAuthor(s): Emiliana Echeverría, Ana Julia Velez Rueda, Maia Cabrera, Ezequiel Juritz, Valeria Burghi, Lucas Fabián, Carlos Davio, Pablo Lorenzano Menna, Natalia Cristina FernándezAbstractAimsG protein-coupled receptor (GPCR) kinases (GRKs) are mainly involved in the desensitization of GPCRs. Among them, GRK2 has been described to be upregulated in many pathological conditions and its crucial role in cardiac hypertrophy, hypertension, and heart failure promoted the search for pharmacological inhibitors of its activity. There have b...
Publication date: Available online 14 September 2019Source: The American Journal of SurgeryAuthor(s): Chad Hall, Justin L. Regner, Thomas Schroeppel, Joe Rodriguez, Robert McIntyre, Franklin Wright, Sharmila Dissanaike, Robyn Richmond, Ariel Santos, Richard C. FrazeeAbstractBackgroundSeveral options exist for the diagnosis and management of suspected common duct stones. We hypothesized that a protocol-directed approach would shorten length of stay in this patient population.MethodsPatients from four participating institutions with a peak bilirubin
We examined the relationship between worry about pregnancy health and pre-eclampsia. General stress, mental health, and self-reported pregnancy health worry were measured in a study of 10,037 U.S. nulliparous women. Logistic regression found a dose-response relationship between first trimester pregnancy-health worry and subsequent pre-eclampsia onset, controlling for health history (Beta = 0.40, SE = 0.09, P
Conclusions: Targeted testing among adults between 39 and 64 years with anti-HCV antibody once per their life in Bulgaria could be considered as cost-effective and provides benefits both for the paying institutions and the patients. PMID: 31514552 [PubMed - as supplied by publisher]
CONCLUSIONS: MitraClip procedure improved life-years and quality of life in patients at high surgical risk and it was also a cost-effective treatment option. PMID: 31516049 [PubMed - as supplied by publisher]
In conclusion, our findings showed that a dherence to healthy diet can decrease oxidative stress and inflammation and accumulation of amyloid-β and consequently can decrease the risk of AD.
This study found that combinations of several factors may be contributing to a high maternal death rate. Most notably, transport, delay management initiation after admission and referral factors account for the majority of maternal deaths. What is the implication of these findings for clinical practice/or further research? Identification of potential problems could assist context-based management of problems. It helps in improving the level of practical skills for the management of pregnancy-related complications like hypertension. It also solves problems in the health services system like access to interventions. It insis...
Conclusion: The DEX-induced inhibition of phagocytosis may be caused by the downregulation of ABR and GULP1 disrupting the αvβ5 integrin/RAC1-mediated engulfment pathway. The downregulation of GULP1 by αvβ3 integrin further suggests that this integrin may be a negative regulator of phagocytosis by transcriptionally downregulating proteins needed for phagocytosis. In summary, these results represent new insights into the effects of glucocorticoids and integrin signaling on the phagocytic process in the TM. PMID: 31516309 [PubMed - in process]