O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress
Hepatocellular carcinoma (HCC) is one of the most common human malignancies and the third leading cause of cancer death worldwide [1]. A retrospective cohort study of indications for adult liver transplantation from 2002 to 2012 revealed a nearly 4-fold increase in patients undergoing liver transplantation for HCC secondary to non-alcoholic steatohepatitis (NASH) compared to only a 2.5-fold increase for HCC secondary to HCV during the study period [2]. With the control of viral hepatitis and the escalating obesity epidemic, nonalcoholic fatty liver disease (NAFLD) associated HCC is occupying a greater proportion of HCC incidence in recent decades [3].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Weiqi Xu, Xiang Zhang, Jian-lin Wu, Li Fu, Ken Liu, Dabin Liu, George Gong Chen, Paul Bo-san Lai, Nathalie Wong, Jun Yu Source Type: research
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