The role of histamine in the regulation of the viability, proliferation and transforming growth factor β1 secretion of rat wound fibroblasts.
CONCLUSION: The regulatory influence of histamine on wound fibroblast function (viability/metabolic activity or secretion of TGFβ1) is dependent on H1 receptor stimulation. Contrary to wound fibroblasts, these cells express a very low level of H1 receptors when isolated from intact dermis and histamine is unable to modify their metabolic activity.
PMID: 28178593 [PubMed - indexed for MEDLINE]
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Wolak M, Bojanowska E, Staszewska T, Ciosek J, Juszczak M, Drobnik J Tags: Pharmacol Rep Source Type: research