Nanotechnology As Potential Tool for siRNA Delivery in Parkinson's Disease.

Nanotechnology As Potential Tool for siRNA Delivery in Parkinson's Disease. Curr Drug Targets. 2017 Mar 21;: Authors: Cortés H, Alcalá-Alcalá S, Ávalos-Fuentes A, Mendoza-Muñoz N, Quintanar-Guerrero D, Leyva-Gómez G, Florán B Abstract The lack of an outright treatment for Parkinson's disease (PD) is a pivotal concern in medicine and has driven the search for novel alternatives for treating the disease. Among the proposed approaches, small interfering RNA (siRNA)-based therapy is attracting significant attention as a potential method for the treatment of PD; however, siRNAs delivery possesses potential drawbacks, such as reduced stability in blood circulation and low capacity for reaching the target site. Therefore, siRNA delivery to the brain is a key issue that remains unsolved to date. In this regard, nanoparticles are being developed as carriers for siRNAs and represent an alternative to common vectors; the formulation of siRNAs in nanoparticles would possess several advantages over other vectors, such as controlled delivery and low toxicity profiles. Therefore, in this article we focus on siRNA-based approaches to PD and the latest advances for designing nanoparticles that effectively target siRNAs to the action site and that protect these against degradation in blood circulation. Additionally, we discuss the technological aspects for tackling the challenge that siRNAs targeting to the brain represents. PMID: 28325...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research