Calcium Transport and Signaling in Mitochondria.

Calcium Transport and Signaling in Mitochondria. Compr Physiol. 2017 Mar 16;7(2):623-634 Authors: Bravo-Sagua R, Parra V, López-Crisosto C, Díaz P, Quest AF, Lavandero S Abstract Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ubiquitous nature, the regulation of both is deeply intertwined, whereby Ca2+ regulates mitochondrial functions, while mitochondria shape Ca2+ dynamics. Deregulation of either Ca2+ or mitochondrial signaling leads to abnormal function, cell damage or even cell death, thereby contributing to muscle dysfunction or cardiac pathologies. Moreover, altered mitochondrial Ca2+ homeostasis has been linked to metabolic diseases like cancer, obesity, and pulmonary hypertension. In this review article, we summarize the mechanisms that coordinate mitochondrial and Ca2+ responses and how they affect human health. © 2017 American Physiological Society. Compr Physiol 7:623-634, 2017. PMID: 28333383 [PubMed - in process]
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research