Intraoperative Brachytherapy for Central Nervous System Lesions: A Validation Study of a Radioactive Seed Loading Device
Condition: Central Nervous System Lesion Intervention: Device: GammaTile seed loader Sponsors: St. Joseph's Hospital and Medical Center, Phoenix; Arizona Commerce Commission, Phoenix AZ; GammaTile, LLC Recruiting - verified March 2017
The purpose of the study was to establish, using a retrospective analysis of existing hospital records, the long-term stability and accuracy of a high-dose-rate brachytherapy well chamber. This should be assessed to determine reliability and appropriate calibration frequency. The accrual of long-term data that demonstrates the stability of our chamber may inform others of the performance they might expect from similar equipment.
This has reference to the research article “Total reference air kerma can accurately predict isodose surface volumes in cervix cancer brachytherapy. A multicenter study.” published in your esteemed journal. The publication is good and informative; we wish to clarify following statements.
Safe delivery of brachytherapy and establishing a safety culture are critical in high-quality brachytherapy. The American Brachytherapy Society (ABS) Quality and Safety Committee surveyed members regarding brachytherapy services offered, safety practices during treatment, quality assurance procedures, and needs to develop safety and training materials.
Despite a preponderance of data demonstrating strong clinical outcomes and cost-effectiveness, prostate brachytherapy use and competency continue to decline. Enhanced resident education may help reverse this trend. We therefore developed and implemented a simulation-based medical education course for low-dose-rate prostate brachytherapy (LDR-PB).
We report feasibility and early outcomes with the use of these hybrid applicators at our institution.
We present a simple and generic outline that lays out the process for developing and implementing a new HDR brachytherapy program in any setting, but with particular emphasis on challenges associated with starting the program in a limited resource setting.
India has a longstanding tradition in the practice of brachytherapy and has actively contributed to the scientific literature by conducting prospective studies, clinical audits, developing innovative techniques, and performing randomized studies. Indian investigators have also contributed to international collaborative research, education, training programs along with guideline development for brachytherapy in cervix and head and neck cancers. The present article summarizes the key contributions to scientific literature, current infrastructure, skill set for brachytherapy, existing challenges, and strategy to further stren...
The recent update of the web-based GEC-ESTRO handbook of brachytherapy  has brought into attention the lack of standardized constraints based on dose volume histogram (DVH) data in head and neck brachytherapy. This is specially noteworthy in an anatomical area where treatment complications may be severe in a substantial number of cases.
Conclusions: There may be dosimetric advantages to VMAT over HDR-SA brachytherapy for many patients. However, individual tumor location, patient anatomy, and treatment reproducibility may result in HDR-SA brachytherapy being the preferred technique in a subset of patients. Ultimately, a personalized approach is likely to be the optimal treatment plan. PMID: 32908445 [PubMed]
CONCLUSIONS: LR is clinically non-inferior or partially superior to HR for CC treatment using HDR, which dispels concerns of potentially undermined patient outcomes when source replacement is delayed. PMID: 32933759 [PubMed - as supplied by publisher]