The Enigma of Extreme Traumatism: Trauma, Exclusion and their Impact on Subjectivity().

The Enigma of Extreme Traumatism: Trauma, Exclusion and their Impact on Subjectivity(). Am J Psychoanal. 2017 Mar 21;: Authors: Viñar MN Abstract My aim is to discuss the immediate effects of extreme trauma and to speculate on its long term effects. The formulations associated with the Post Traumatic Stress Syndrome generate an overly medicalized view of trauma, grossly underestimating its devastating impact. Catastrophic traumatic experience rips a hole in the representational continuity of psychic life; neither representations nor narrations are generated. Instead, a representational emptiness occurs, such that what has taken place cannot be shared or transmitted. The cathartic word becomes a robotic mocking of the interchange between human beings. There is no internalization, no ability to make the experience subjective. The resulting deep splitting in the psyche is characteristic of extreme traumatism, and its balance or perpetual working through is elaborated in this paper. PMID: 28325939 [PubMed - as supplied by publisher]
Source: American Journal of Psychoanalysis - Category: Psychiatry & Psychology Authors: Tags: Am J Psychoanal Source Type: research

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This study was aimed at determining how 5-HT2A and 5-HT1A receptors mediate stress-induced anxiety-like behavior. C57BL/6 mice were exposed to conditioned fear stress combined with single-prolonged stress and injected with corresponding antagonists of 5-HT2A or 5-HT1A receptors or DMSO. The established mouse model was used in conjunction with open-field test, freezing behavioral test and elevated plus maze test. Protein expression levels of 5-HT2A and 5-HT1A receptors, ERK1 and ERK2, pERK1, pERK2 and c-Myc in mice hippocampus were evaluated by Western blot analysis and immunofluorescence labeling. Relative mRNA expression ...
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Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
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