Association of ORAI1 gene polymorphisms with chronic spontaneous urticaria and the efficacy of the nonsedating H1 antihistamine desloratadine

Chronic spontaneous urticaria (CSU) is a common skin disease associated with mast cell activation and degranulation.1,2 The degranulation process of mast cells is mediated mainly by calcium-release –activated calcium channels–mediated Ca2+ influx. ORAI1, encoded by ORAI1 gene, is the pore-forming subunit of calcium-release–activated calcium channels.3-5 A study on ORAI1 knockout mouse demonstrated that ORAI1 is essential for mast cell degranulation, leukotriene (LTC4) secretion, histami ne release as well as TNF-α secretion.

Source: Journal of Allergy and Clinical Immunology - November 15, 2016 Category: Allergy & Immunology Authors: Jie Li, Aiyuan Guo, Wangqing Chen, Lianghua Bin, Yijing He, Wu Zhu, Cong Peng, Siyu Yan, Mingliang Chen, Jianglin Zhang, Juan Su, Mei Yi, Zhaoqian Liu, Wei Zhang, Weiqi Zeng, Donald Y.M. Leung, Xiang Chen Tags: Letter to the Editor Source Type: research