Systemic sclerosis: Antifibrotic effects of PDE4 blockade?

Nature Reviews Rheumatology 13, 198 (2017). doi:10.1038/nrrheum.2017.34 Author: Sarah Onuora New research published in Annals of the Rheumatic Diseases suggests inhibition of phosphodiesterase 4 (PDE4) could have disease-modifying antifibrotic effects in systemic sclerosis (SSc), particularly in those patients with inflammation-driven fibrosis. In preclinical models of SSc, PDE4 blockade prevented progression of chronic fibrosis and
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Tags: Research Highlight Source Type: research