Combined Typical Carcinoid-Adenocarcinoma Lung Tumor

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Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Online Articles: Letters to the Editor Source Type: research

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Spread through air spaces (STAS) is a hype and assumed to be another way for tumor cells to permeate lung parenchyma beyond classical invasion criteria (stroma, patterning and lymphovascular spaces) [1], which is increasingly described at the growing edges of adenocarcinoma [2,3], squamous cell carcinoma [4], sarcomatoid carcinoma [5] and neuroendocrine (NE) neoplasms [6,7], with worrisome implications for tumor recurrence, reduced survival and parenchyma-sparing resections [8 –11]. STAS was officially introduced in the 2015 World Health Organization classification for adenocarcinoma [1], but aerogenous spread as a s...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsThe results from our study have further established the high sensitivity and specificity of INSM1 in the largest pulmonary cytologic and surgical cohorts to date. INSM1 either matched or outperformed the performance of existing neuroendocrine markers, and its combination with CD56 appeared to maximize test performance.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
CONCLUSION: The history of renal scleroderma crisis and the positivity of anti-topoisomerase I antibodies were associated with an increased risk of cancer in SSc patients in this monocentric study. PMID: 31255252 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
ConclusionPrimary tumors of the trachea remain of reserved prognosis with 5-year survival of 57% of all histological types combined. Computed tomodensitometry and tracheobronchial fibroscopy remain the means of reference exploration in the diagnosis and assessment of surgical resectability.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
ConclusionPrimary tumors of the trachea remain of reserved prognosis with 5-year survival of 57% of all histological types combined. Computed tomodensitometry and tracheobronchial fibroscopy remain the means of reference exploration in the diagnosis and assessment of surgical resectability.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
In conclusion, the presence of STAS is an additional relevant adverse prognostic factor in pulmonary AC that currently has the most unpredictable outcome and the most controversial treatment strategy.
Source: Virchows Archiv - Category: Pathology Source Type: research
This study aimed to report a case of gastrointestinal stromal tumor in the jejunal region in a patient with type 1 neurofibromatosis, followed-up for two years, who underwent laparoscopic segmental enterectomy and diagnosis determined by histopathology and immunohistochemistry. The diagnosis of small intestine gastrointestinal stromal tumor is challenging because of its low incidence, nonspecific symptoms, relative inaccessibility of the small intestine to conventional endoscopic examination, broad spectrum of radiological appearances, and the fact that the nature of the mass is difficult to determine with imaging examinat...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
We present a case of a 71 year old female with a history of Barrett's esophagus with high grade dysplasia that on screening endoscopy was found to have a squamous patch proximal to the gastroesophageal junction and underwent an endoscopic mucosal resection. Within the resection, there was a small tumor with a monomorphic population with speckled nuclear chromatin located within the lamina propria extending into the muscularis mucosae. The tumor measured 1 mm in greatest dimension and the overlying epithelium showed no evidence of the presence of Barrett's esophagus. Immunohistochemical staining of the tumor was consist...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
The term goblet cell carcinoid was first proposed in 1974 by Subbuswamy et al for a rare tumor of the appendix. Since then, it has been debated whether these tumors should be regarded as adenocarcinomas or as neuroendocrine tumors. Research on these neoplasms has been hampered by their rarity and the low density of tumor cells. However, their particular morphology legitimates their classification as an entity specific for the appendix. In this review the morphology, immunohistochemical profile and differential diagnosis are discussed. Recent literature on grading and molecular profiling is reviewed. These data show that gr...
Source: Pathology Case Reviews - Category: Pathology Tags: Reviews Source Type: research
Conclusion: Our data supports that never/ever smoker patients with small-cell lung cancer have better prognosis compared to their smoker counterparts. Further, patients with never/ever smoking history who present with small-cell lung cancer have a different mutation profile compared with smokers, including a high frequency of EGFR, MET, and SMAD4 mutations. Further studies are required to assess whether the differential mutation profile is a consequence of a diverse pathological mechanism for disease onset. Introduction Lung cancer is the most common neoplasia worldwide. Aside from the high incidence, lung cancer a...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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