Pretreatment with ALDH2 agonist Alda-1 reduces intestinal injury induced by ischemia and reperfusion in mice

This study was to determine whether ALDH2 agonist, Alda-1, could alleviate intestinal injury after gut IR. In a mice model of intestinal IR injury, histological grading, proinflammatory cytokines, oxidative stress, cellular apoptosis, chemokine contents, ALDH2 activity, 4-HNE and MDA were evaluated. The results indicated that IR treatment conferred elevation in pathological scores, proinflammatory cytokines, oxidative stress, cellular apoptosis, chemokine levels, accompanied by accumulated 4-HNE and MDA. No significant changes in ALDH2 activity were observed after IR. However, Alda-1 pretreatment significantly decreased these injurious indicators, concomitant with up-regulated ALDH2 activity and mitigated 4-HNE and MDA accumulation. Taken together, our results implicate that activating ALDH2 by Alda-1 significantly abated intestinal IR injury.

Source: Clinical Science - March 21, 2017 Category: Biomedical Science Authors: Zhu, Q., He, G., Wang, J., Wang, Y., Chen, W. Tags: PublishAheadOfPrint Source Type: research