Cryogenic preservation: from single cells to whole organs – Science Weekly podcast

Hannah Devlin looks at recent advances in the field ofcryopreservation and asks how close we are to applying these technologies to whole organsSubscribe&Review oniTunes,Soundcloud,Audioboom,Mixcloud&Acast, and join the discussion onFacebook andTwitterLast year, around 3,500 organs were transplanted into patients in the UK alone. That said, a large number of organs were also discarded because the moment a donor dies, doctors have only eight or so hours to find a patient on the organ register who is a match and can be almost immediately ready for surgery. One recent estimate suggested that as many as 60% of the hearts and lungs donated for transplantation are discarded each year. But a new technology could be about to change this: whole-organ cryopreservation.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Organ donation Health Society Source Type: news

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One of the most promising strategies to increase organ donation is the use of organs from donors with Hepatitis C (HCV). We evaluated the safety of transplanting NAT+HCV donors into non-infected lung recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 136 Source Type: research
Heart donation after circulatory death (DCD) has significantly improved organ utilisation with promising early outcomes. To date, adult DCD heart programmes have relied largely on ex-situ heart perfusion during transport of the donor organs even after normothermic regional perfusion (NRP) in the donor where the heart is formally assessed after circulatory arrest. In this pre-clinical porcine study we compare the use of cold storage as an alternative to ex-situ heart perfusion following NRP.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 591 Source Type: research
Evaluation of a potential lung graft in an ex-vivo lung perfusion (EVLP) system has gained an increased use among transplantation centers. Current standard of organ assessment before transplantation with machine perfusion are performed with normothermic temperature but sub-normothermic setting is under clinical use among several solid organs. Our aim was to investigate the impact of sub-normothermic EVLP from donation after circulatory death donor lungs in a rat model.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 573 Source Type: research
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins. Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Human body is intertwined collection of lives of Individual organs.We believe death occurs when brain dies , respiration stops and circulation ceases . Curiously ,when life ends , these organs  don’t die as a single unit . These three events can happen in any of the six possible permutations.Each organ takes different times to die after loss of life.It is like a crashed computer , where the mother board /RAM memory may be transferred to another and be functional . Out of these three , heart function appears to be supreme as it can function without the need of brain (Science of brain-death) and keep the body...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Heart transplantation donor heart transport transmedics Source Type: blogs
Discussion of Mitochondrial Hormesis as an Approach to Slow Aging Cornelis (Cees) Wortel, Ichor Therapeutics Chief Medical Officer, on Rejuvenation Research and Its Engagement with the Established Regulatory System An Interview with a Programmed Aging Theorist An Interview with Reason at the Life Extension Advocacy Foundation An Interview on Mitochondrial Damage and Dysfunction in Aging An Interview with Vadim Gladyshev on Research into the Causes of Aging An Interview with Jim Mellon, and Update on Juvenescence A Lengthy Interview with Aubrey de Grey of the SENS Research Foundation An Interview with Peter de Keize...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
CONCLUSIONS Management by dedicated intensivists will improve not only the number of actual organ donors, but also the number of harvested organs. PMID: 30510153 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Abstract Donors after brain death (DBD) have been the major source of organ donation due to good perfusion of the organs. However, owing to the mismatch in demand and supply of the organ donors and recipients, donors after circulatory death (DCDDs) has increased recently all over the world. Kidneys, liver, and lungs are being used for transplantation from DCDDs. Recently, heart transplantation from DCDDs has been started, which is under the firestorm of scrutiny by the ethicists. The ethical dilemma revolves around the question whether the donors are actually dead when they are declared dead by cardiocirculatory d...
Source: Indian Heart J - Category: Cardiology Authors: Tags: Indian Heart J Source Type: research
dil;E, Cebeci H, Aydın D, Ülger F Abstract Organ donation is a matter of concern in critically ill patients who need intensive care after carbonmonoxide (CO) intoxication. A 26-year-old female patient was unconscious after having spent 20 minutes in the bathroom with a water heater (70% butane and 30% propane mixture). In the CT of the patient with Glasgow Coma Scale (GCS) 3, ventricular system was erased, white-gray matter separation was lost and fissures were observed as erased. Torax CT showed conspicuous areas showing air bronchograms in both lung bases and posterior areas and diffuse frosted glass densi...
Source: Tuberkuloz ve Toraks - Category: Respiratory Medicine Authors: Tags: Tuberk Toraks Source Type: research
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