Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells.

In conclusion, our data suggest that silencing of DIRAS3 in ASCs and subsequently hyper-activation of Akt-mTOR drives adipogenesis and premature senescence. Moreover, differentiating ASCs and/or mature adipocytes may acquire features of cellular senescence. PMID: 28316325 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28316325?dopt=Abstract

Source: Aging - March 17, 2017 Category: Biomedical Science Authors: Ejaz A, Mattesich M, Zwerschke W Tags: Aging (Albany NY) Source Type: research