Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy

ConclusionsOur results suggest that only aging female ApoE-deficient but not WT mice develop severe PH compared to younger females. Exogenous estrogen therapy rescued PH and RV hypertrophy in aging female ApoE-deficient mice possibly through restoration of lung ER β.

http://link.springer.com/10.1186/s13293-017-0129-7

Source: Biology of Sex Differences - March 19, 2017 Category: Biology Source Type: research