18 β-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model

Publication date: Available online 20 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Seung-Hyung Kim, Jung-hee Hong, Ji-Eun Lee, Young-Cheol Lee 18β-Glycyrrhetinic acid (18Gly), the major bioactive component of Glycyrrhizae Radix, possesses anti-ulcerative, anti-inflammatory, and other pharmacological properties. Although 18Gly is associated with immunoregulatory functions of allergic diseases, the pathophysiological mechanisms of 18Gly action in allergic inflammatory lung disease have not been examined. Moreover, there are no in vivo studies on the anti-asthmatic effects of 18Gly in allergic asthma. We investigated its effect and mechanism of action in airway inflammation in a BALB/c mouse model of allergic asthma. Interestingly, 18Gly strongly suppressed airway hyperresponsiveness, accumulation of inflammatory cells, and levels of T helper type 2 (Th2) cytokines (interleukin (IL)-5 and IL-13) in bronchoalveolar lavage fluid (BALF). It also attenuated lung IL-5, IL-13, and IL-4 expression, but it upregulated peroxisome proliferator-activated receptor gamma (PPARγ) mRNA expression in lungs. Moreover, it exerted immunomodulatory effects by suppressing Th2 cytokines (IL-5, IL-13) production through upregulation of forkhead box p3 (Foxp3), and downregulation of signal transducer and activator of transcription (STAT6), GATA-binding protein 3 (GATA-3), and retinoic acid-related orphan receptor γ t (RORγt) expression. These results su...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

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Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
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Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
Environmental nonallergenic exposures, such as microbes and air pollutants, are thought to influence the clinical manifestations of allergic and atopic disease. However, as patterns of urbanization, climate change, and socioeconomic health disparities persist, the health effects of the envirome are increasingly relevant to practitioners and policymakers. In this issue of Annals, Peden1 outlines the influence of pollutant, infectious, and psychosocial conditions on the incidence and severity of allergic disease.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
The goal of personalized medicine is arguably as old as medicine itself,1 and the promise of using simultaneously broad (all genes and all exposures), precise (single molecules or cells), and unbiased (not dependent on prior knowledge) data sets to tailor clinical care is the compelling objective of systems biology as applied to medicine. In this issue, Virkud et  al2 present a useful and informative overview of the “big data” domains, including genomics, epigenomics, transcriptomics, and proteomics along with the microbiome and exposome and their integrated effects on the metabolome, which are the grist f...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
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Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
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Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
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Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
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